期刊范围涵盖风湿病研究的整个范围。我们确保我们的文章可供最广泛的受众访问。

Nature Reviews Rheumatology covers the entire spectrum of rheumatology research. We are committed to ensuring that our articles are accessible to the widest possible audience.

《Nature Reviews Rheumatology》期刊涵盖了风湿病研究的各个领域。我们致力于确保我们的文章能够被最广泛的受众所访问。

Nature Reviews Rheumatology

Blood vessels form a versatile transport network that is best known for its critical roles in processes such as tissue oxygenation, metabolism and immune surveillance. The vasculature also provides local, often organ-specific, molecular signals that control the behaviour of other cell types in their vicinity during development, homeostasis and regeneration, and also in disease processes. In the skeletal system, the local vasculature is actively involved in both bone formation and resorption. In addition, blood vessels participate in inflammatory processes and contribute to the pathogenesis of diseases that affect the joints, such as rheumatoid arthritis and osteoarthritis. This Review summarizes the current understanding of the architecture, angiogenic growth and functional properties of the bone vasculature. The effects of ageing and pathological conditions, including arthritis and osteoporosis, are also discussed.

Jan Tuckermann

Ralf H Adams

Nature reviews. Rheumatology

Nat Rev Rheumatol

The endothelium-bone axis in development, homeostasis and bone and joint disease.

内皮-骨骼轴在发育、稳态及骨关节疾病中的作用。

Lupus nephritis is a common complication of systemic lupus erythematosus (SLE) and a determinant of overall morbidity and mortality, as lupus nephritis-related chronic kidney disease (CKD) drives cardiovascular disease and secondary immunodeficiency. Two lines of action are required to prevent the progression of lupus nephritis-related CKD: suppression of autoimmune SLE activity, which is a risk factor for immunopathology-related irreversible kidney injury, and management of non-immune risk factors that contribute to CKD progression. As each episode or relapse of active lupus nephritis implicates CKD progression, preventing flares of lupus nephritis is a key treatment target. Non-immune risk factors of CKD mostly include causes of nephron hyperfiltration, such as obesity, hypertension, sodium- or protein-rich diets and type 2 diabetes mellitus, as well as pregnancy. Nephrotoxic agents and smoking also drive kidney cell loss. Intrinsic risk factors for CKD progression include poor nephron endowment because of prematurity at birth, nephropathic genetic variants, ageing, male sex and previous or concomitant kidney diseases. Care for lupus nephritis involves the control of all modifiable risk factors of CKD progression. In addition, remnant nephron overload can be reduced using early dual therapy with inhibitors of the renin-angiotensin system and sodium-glucose transporter-2, whereas further renoprotective drug interventions are underway. As patients with lupus nephritis are at risk of CKD progression, they would all benefit from interdisciplinary care to minimize the risk of kidney failure, cardiovascular disease and infections.

Julia Lichtnekert

Hans-Joachim Anders

Lupus nephritis-related chronic kidney disease

狼疮性肾炎相关慢性肾脏病

Myositis-specific autoantibodies (MSAs) have become pivotal biomarkers for idiopathic inflammatory myopathies and have revolutionized understanding of the heterogeneous disease spectrum that affects both adults and children. The discovery and characterization of MSAs have substantially enhanced patient stratification based on clinical phenotype, thereby facilitating more precise diagnosis and ultimately improving management strategies. Advances in immunoassay technologies in the past 20 years have further propelled the field forward, enabling the detection of a growing repertoire of autoantibodies with high specificity and sensitivity; however, evolving research over the past decade has revealed that even within antibody-defined subsets, considerable clinical diversity exists, suggesting a broader spectrum of disease manifestations than previously acknowledged. Challenges persist, particularly among patients who are seronegative, where the failure to identify certain rare MSAs stems from the use of diverse detection methodologies and inadequate consensus-guided standardization and validation protocols. Bridging these diagnostic gaps is crucial for optimizing patient care and refining prognostic stratification in idiopathic inflammatory myopathies.

Nur Azizah Allameen

Ana Isabel Ramos-Lisbona

Lucy R. Wedderburn

Ingrid E. Lundberg

David A. Isenberg

An update on autoantibodies in the idiopathic inflammatory myopathies

特发性炎性肌病中自身抗体的最新进展

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to bone and transmit forces to produce motion. Chronic and acute tendon injuries are very common and result in considerable pain and disability. The management of tendon injuries remains a challenge for clinicians. Effective treatments for tendon injuries are lacking because the understanding of tendon biology lags behind that of the other components of the musculoskeletal system. Animal and cellular models have been developed to study tendon-cell differentiation and tendon repair following injury. These studies have highlighted specific growth factors and transcription factors involved in tenogenesis during developmental and repair processes. Mechanical factors also seem to be essential for tendon development, homeostasis and repair. Mechanical signals are transduced via molecular signalling pathways that trigger adaptive responses in the tendon. Understanding the links between the mechanical and biological parameters involved in tendon development, homeostasis and repair is prerequisite for the identification of effective treatments for chronic and acute tendon injuries.

Geoffroy Nourissat

Francis Berenbaum

Delphine Duprez

Tendon injury: from biology to tendon repair.

Pain is one of the most debilitating symptoms of rheumatoid arthritis (RA), and yet remains poorly understood, especially when pain occurs in the absence of synovitis. Without active inflammation, experts most often attribute joint pain to central nervous system dysfunction. However, advances in the past 5 years in both immunology and neuroscience research suggest that chronic pain in RA is also driven by a variety of abnormal interactions between peripheral neurons and mediators produced by resident cells in the local joint environment. In this Review, we discuss these novel insights from an interdisciplinary neuro-immune perspective. We outline a potential working model for the peripheral drivers of pain in RA, which includes autoantibodies, resident immune and mesenchymal cells and their interactions with different subtypes of peripheral sensory neurons. We also offer suggestions for how future collaborative research could be designed to accelerate analgesic drug development.

短名	Nat Rev Rheumatol
Journal Impact	29.26
国际分区	RHEUMATOLOGY(Q1)
期刊索引	SCI Q1中科院 1 区

ISSN	1759-4790, 1759-4804
h-index	182
国内分区	医学(1区)医学风湿病学(1区)
Top 期刊	是

涉及主题	医学生物内科学化学病理生物化学免疫学遗传学疾病重症监护医学法学政治学梅德林生物信息学类风湿性关节炎
出版信息	出版商: Nature Research，出版周期: Monthly，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2009，原创研究文献占比: 20.00%，自引率:2.00%， Gold OA占比: 2.76%
平均审稿周期	网友分享经验：较慢,6-12周
平均录用比例	网友分享经验：较难

Nature Reviews Rheumatology

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The endothelium-bone axis in development, homeostasis and bone and joint disease.

Lupus nephritis-related chronic kidney disease

An update on autoantibodies in the idiopathic inflammatory myopathies

Tendon injury: from biology to tendon repair.

An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis

Antigen-specific immunotherapies for autoimmune disease

Inebilizumab shows promise for IgG4-RD

Appraising the evolving landscape of protease inhibition in osteoarthritis

The ‘Treg paradox’ in inflammatory arthritis

Publisher Correction: Lupus nephritis-related chronic kidney disease