原：CURRENT MEDICINAL CHEMISTRY - ANTI-CANCER AGENTS由该领域的领导者撰写的深入评论和客座编辑的问题，涵盖了癌症药物化学的一系列当前主题。该杂志只考虑发表高质量的研究论文。ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 是每一位希望随时了解癌症药物发现最新和最重要进展的药物化学家的重要期刊。

Anti-Cancer Agents in Medicinal Chemistry is a journal authored by leaders in the field, offering in-depth reviews and guest-edited issues that cover a range of current topics in cancer medicinal chemistry. The journal only considers high-quality research papers for publication, making it an essential resource for medicinal chemists who wish to stay informed about the latest and most significant advancements in cancer drug discovery.

《Anti-Cancer Agents in Medicinal Chemistry》是一本由该领域的领导者撰写的期刊，提供深入的评论和特邀编辑的专题，涵盖癌症药物化学的多个当前主题。该杂志只考虑发表高质量的研究论文，是每位希望了解癌症药物发现最新进展的药物化学家的重要参考。

Anti-Cancer Agents in Medicinal Chemistry

Dinesh Kumar Mehta

Rina Das

Anti-cancer agents in medicinal chemistry

Anticancer Agents Med Chem

Current Expansions and Future Perspectives in Anticancer Drug Therapy.

抗癌药物治疗的现状扩展与未来展望

Reactive Oxygen Species (ROS) refers to the highly reactive substances which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen, and hydroxyl radicals are the major examples of ROS. Generally, the reduction of oxygen (O2) in molecular form produces superoxide (•O2 -) anion. ROS are produced during a variety of biochemical reactions within the cell organelles, such as endoplasmic reticulum, mitochondria, and peroxisome. Naturally, ROS are also formed as a byproduct of the normal metabolism of oxygen. The production of ROS can be induced by various factors such as heavy metals, tobacco, smoke, drugs, xenobiotics, pollutants, and radiation. From various experimental studies, it is reported that ROS acts as either a tumor-suppressing or a tumor-promoting agent. The elevated level of ROS can arrest the growth of tumors through the persistent increase in cell cycle inhibition. The increased level of ROS can induce apoptosis by both intrinsic and extrinsic pathways. ROS is considered to be a tumor-suppressing agent as the production of ROS is due to the use of most of the chemotherapeutic agents in order to activate cell death. The cytotoxic effect of ROS provides impetus towards apoptosis, but in higher levels, ROS can cause initiation of malignancy that leads to uncontrolled cell death in cancer cells. In contrast, some species of ROS can influence various activities at the cellular level, including cell proliferation. This review highlights the genesis of ROS within cells by various routes and their role in cancer therapies.

Biswa Mohan Sahoo

Bimal Krishna Banik

Preetismita Borah

Adya Jain

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

活性氧(ROS): 癌症治疗的关键成分

The present application reports a series of novel Arcyriaflavin-A derivatives as PIM kinase inhibitors for the effective treatment of cancer. The application also describes the synthesis of compounds in detail, use, pharmaceutical composition, pharmaceutically acceptable salts, and treatment.

Surya K. De

Novel Arcyriaflavin-A Derivatives as PIM Kinase Inhibitors for Treating Cancer

新型阿日菌素A衍生物作为治疗癌症的PIM激酶抑制剂

Abstract: Breast cancer frequently occurs in women. Among the several types of breast cancers, almost 50% of breast cancers are caused by one or more gene mutations of the PI3K/mTOR/AKT pathway. Capivasertib, the first AKT inhibitor, was authorized by the US FDA on November 16, 2023.. It is used for the treatment of adult patients with hormone receptor-positive, human epidermal growth factor receptor 2 negative metastatic breast cancer with at least one alteration on PIK3CA/AKT1/PTEN. In this short perspective, Capivasertib’s physicochemical properties, synthesis, mechanism of action, binding mode, pharmacokinetics, drug interaction studies, and treatment-emergent adverse events are discussed.

SURYA K DE

Capivasertib: First Approved AKT inhibitor for the Treatment of Patients with Breast Cancer

卡帕塞替尼：首个获批用于乳腺癌患者治疗的AKT抑制剂

Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underlying mechanism of the altered metabolism in CRC is still unknown. Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in 135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated. Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1 showed a significantly strong link with FOXM1 in CRC tissue. Conclusions: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.

Xiao-Yi Kuai

Zhi-Yi Lei

Xiao-Shuang Liu

Xin-Yu Shao

The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer

GLUT1 与 FOXM1 相互作用导致结直肠癌预后不良

Background: Phytochemicals have long remained an essential component of the traditional medicine system worldwide. Advancement of research in phytochemicals has led to the identification of novel constituents and metabolites from phytochemicals, performing various vital functions ranging from antimicrobial properties to anticarcinogenic roles. This plant is traditionally used by local people to manage inflammation. In this study, we aim to extract and chemically profile the essential oil from the leaves of Cleistocalyx operculatus (Roxb.) Merr. &amp; Perry and study of the anti-inflammatory and anti-proliferative role of essential oil. Methods: The hydro distillation method was used for the extraction of essential oil, and the GC-MS was applied for the chemical profiling. The percentage of cell viability was calculated using a crystal violet assay, colony formation assay was performed using Semiquantitative PCR, Propodium iodite staining was used for cell death assay, and Western blotting was used to determine antibodies and proteins. Schrodinger 2015 software was used for molecular docking. Results: Myrcene, a monoterpene, constitutes 56% of the oil and could be attributed to its anti-inflammatory potential. Treatment of LPS-challenged mouse macrophages RAW264.7 cells with essential oil resulted in a decline in the inflammatory markers, such as IL-1β, TNFα, iNOS, COX-2, and NFκB. Further, essential oil inhibited cancer PC-3, A431, A549, and MCF-7 cell lines at concentrations lower than normal PNT2 and HEK-293 cell lines. This decline in proliferative potential can be attributed to a decline in anti-apoptotic proteins, such as procaspase 3 and PARP, an increase in CKIs, such as p21, and a decline in the Akt signaling responsible for survival. Conclusion: The essential oil of the plant Cleistocalyx operculatus may be a potential lead for anti-inflammatory and anti-proliferative function.

Vivek Pandey

Sumnath Khanal

Nerina Shahi

Rupak Parajuli

Achyut Adhikari

Yuba Raj Pokharel

Anti-Inflammatory and Anti-proliferative Role of Essential Oil of Leaves of Cleistocalyx operculatus (Roxb.) Merr. &amp; Perry

闭鞘姜（Cleistocalyx operculatus）叶精油的抗炎和抗增殖作用

Simone Carradori

Preface

前言

The development of new therapies targeting crucial kinases involved in cancer progression is a promising area of research. Pyrazolo pyrimidine derivatives have emerged as potential candidates for this purpose.

Praveen Kumar Bandaru

Satya Kameswara Rao N

Shyamala P

Amide Functionalized Novel Pyrrolo-pyrimidine Derivative as Anticancer Agents: Synthesis, Characterization and Molecular Docking Studies

酰胺功能化新型吡咯并嘧啶衍生物作为抗癌药物：合成、表征及分子对接研究

Gratiola officinalis L. (hedge hyssop), a medicinal plant of the Scrophulariaceae family, has diuretic, purgative, and vermifuge properties. It is used as a herbal tea to treat chronic gastroenteritis, renal colic, jaundice, and intestinal worms. Previously, we have found that an extract from G. officinalis is nontoxic and has antitumor, antioxidant, antimicrobial, antiinflammatory, anticachexic, and other properties. Our aims in this study were to separate the G. officinalis extract into individual fractions, to identify the most biologically active fractions, and to examine the chemical composition of these fractions and their biological activity toward A498 renal carcinoma cells.

Alexander Shirokov

Vyacheslav Grinev

Matvey Kanevskiy

Yulia Fedonenko

Larisa Matora

Natalya Polukonova

Dmitry Mudrak

Artyom Mylnikov

Anna Polukonova

Alla Bucharskaya

Nikita Navolokin

Galina Maslyakova

Composition and Biological Activity of Flavonoid-containing Fractions of an Extract from Gratiola officinalis L.

药用植物Gratiola officinalis L.提取物中含黄酮类组分的组成及生物活性

Abbreviation	ACAMC
Journal Impact	2.71
Quartiles(Global)	ONCOLOGY(Q3)

ISSN	1871-5206, 1875-5992
h-index	108

Publication Information	Publisher: Bentham Science Publishers，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2006，Proportion of original research papers: 63.41%，Self Citation Rate:3.80%， Gold OA Rate: 1.69%
Average review cycle	网友分享经验：偏慢,4-8周
Average recruitment ratio	网友分享经验：较易

Anti-Cancer Agents in Medicinal Chemistry

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Current Expansions and Future Perspectives in Anticancer Drug Therapy.

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

Novel Arcyriaflavin-A Derivatives as PIM Kinase Inhibitors for Treating Cancer

Capivasertib: First Approved AKT inhibitor for the Treatment of Patients with Breast Cancer

The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer

Capivasertib: First Approved AKT inhibitor for the Treatment of Patients with Breast Cancer

Anti-Inflammatory and Anti-proliferative Role of Essential Oil of Leaves of Cleistocalyx operculatus (Roxb.) Merr. & Perry

Preface

Amide Functionalized Novel Pyrrolo-pyrimidine Derivative as Anticancer Agents: Synthesis, Characterization and Molecular Docking Studies

Composition and Biological Activity of Flavonoid-containing Fractions of an Extract from Gratiola officinalis L.