ACS APPLIED MATERIALS & INTERFACES 是一本面向化学家、工程师、物理学家和生物学家的跨学科社区的新出版物，重点关注如何开发新发现的材料和界面过程并将其用于特定应用。该杂志除了发表致力于推进应用材料研究的评论和论坛外，还发表来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces is an interdisciplinary journal aimed at chemists, engineers, physicists, and biologists, focusing on the development of newly discovered materials and interface processes for specific applications. The journal publishes not only reviews and forums that advance applied materials research but also full articles and letters from researchers in academia and industry.

《ACS Applied Materials and Interfaces》是一本面向化学家、工程师、物理学家和生物学家的跨学科期刊，专注于新材料和界面过程的开发及其特定应用。该杂志不仅发表推动应用材料研究的评论和论坛，还刊登来自学术界和工业界研究人员的完整文章和信件。

ACS Applied Materials and Interfaces

In the face of the abundant production of various types of carbapenemases, the antibacterial efficiency of imipenem, seen as "the last line of defense", is weakening. Following, the incidence of carbapenem-resistant Acinetobacter baumannii (CRAB), which can generate antibiotic-resistant biofilms, is increasing. Based on the superior antimicrobial activity of silver nanoparticles against multifarious bacterial strains compared with common antibiotics, we constructed the IPM@AgNPs-PEG-NOTA nanocomposite (silver nanoparticles were coated with SH-PEG-NOTA as well as loaded by imipenem) whose core was a silver nanoparticle to address the current challenge, and IPM@AgNPs-PEG-NOTA was able to function as a novel smart pH-sensitive nanodrug system. Synergistic bactericidal effects of silver nanoparticles and imipenem as well as drug-resistance reversal via protection of the β-ring of carbapenem due to AgNPs-PEG-NOTA were observed; thus, this nanocomposite confers multiple advantages for efficient antibacterial activity. Additionally, IPM@AgNPs-PEG-NOTA not only offers immune regulation and accelerates tissue repair to improve therapeutic efficacy in vivo but also can prevent the interaction of pathogens and hosts. Compared with free imipenem or silver nanoparticles, this platform significantly enhanced antibacterial efficiency while increasing reactive oxygen species (ROS) production and membrane damage, as well as affecting cell wall formation and metabolic pathways. According to the results of crystal violet staining, LIVE/DEAD backlight bacterial viability staining, and real-time quantitative polymerase chain reaction (RT-qPCR), this silver nanocomposite downregulated the levels of ompA expression to prevent formation of biofilms. In summary, this research demonstrated that the IPM@AgNPs-PEG-NOTA nanocomposite is a promising antibacterial agent of security, pH sensitivity, and high efficiency in reversing resistance and synergistically combatting carbapenem-resistant A. baumannii. In the future, various embellishments and selected loads for silver nanoparticles will be the focus of research in the domains of medicine and nanotechnology.

Xisheng Li

Rong Gui

Jian Li

Rong Huang

Yinghui Shang

Qiangqiang Zhao

Haiting Liu

Haiye Jiang

Xueling Shang

Xin Wu

Xinmin Nie

ACS Applied Materials & Interfaces

ACS Appl. Mater. Interfaces

Novel Multifunctional Silver Nanocomposite Serves as a Resistance-Reversal Agent to Synergistically Combat Carbapenem-Resistant Acinetobacter baumannii

A photocrosslinkable gelatin methacryloyl (GelMA) hydrogel has been widely examined in regenerative engineering because of its good cell–tissue affinity and degradability in the presence of matrix metalloproteinases. A halloysite aluminosilicate nanotube (HNT) is a known reservoir for the loading and sustained delivery of therapeutics. Here, we formulate injectable chlorhexidine (CHX)-loaded nanotube-modified GelMA hydrogel that is cytocompatible and biodegradable and provides sustained release of CHX for infection ablation while displaying good biocompatibility. The effects of HNTs and CHX on hydrogel degradability and mechanical properties, as well as on the kinetics of CHX release, and on the antimicrobial efficacy against oral pathogens were systematically assessed. Cytocompatibility in stem cells from human exfoliated deciduous teeth and inflammatory response in vivo using a subcutaneous rat model were determined. Our hydrogel system, that is, (CHX)-loaded nanotube-modified GelMA showed minimum localized inflammatory responses, supporting its ability for drug delivery applications. Moreover, we showed that the incorporation of CHX-loaded nanotubes reduces the mechanical properties, increases the swelling ratio, and diminishes the degradation rate of the hydrogels. Importantly, the presence of CHX-loaded nanotubes inhibits bacterial growth with minimal cell toxicity. Our findings provide a new strategy to modify GelMA hydrogel with chlorhexidine-loaded nanotubes for clinical use as an injectable drug delivery strategy for dental infection ablation.

Juliana S. Ribeiro

Ester A. F. Bordini

Jessica A. Ferreira

Ling Mei

Nileshkumar Dubey

J. Christopher Fenno

Evandro Piva

Rafael G. Lund

Anna Schwendeman

Marco C. Bottino

Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation

Physicians have long been calling for an inherent antimicrobial wound dressing, which will be a great progress for treating complicated infections. Here, we report a novel bioadhesive hydrogel with inherent antibacterial properties prepared by mixing modified hyaluronic acid (HA) and ε-polylysine (EPL). This hydrogel can effectively kill Gram (+) and (−) bacteria for its high positive charge density on the surface. The sol–gel transition occurs within seconds via horseradish peroxidase enzymatic cross-linking and Schiff base reaction, which also allows the hydrogel to recover completely from destruction quickly within 5 min. In an infected rat wound model, histological studies indicated that the hydrogels effectively killed bacteria on the surface of wounds and accelerated wound healing. Histological analysis indicated that the thickness of the newborn skin, the density of the newborn microvascular, granulation tissue, and the collagen of rats treated with hydrogel dressings were twice as high as those treated by commercial fibrin glue. These results indicate that the HA/EPL hydrogel has great potential as an antibacterial wound dressing for future clinical applications.

Shuai Liu

Xin Liu

Yanhan Ren

Penghui Wang

Yajie Pu

Rong Yang

Xiaoxue Wang

Xiaoyan Tan

Zhiwen Ye

Victor Maurizot

Bo Chi

Mussel-Inspired Dual-Cross-linking Hyaluronic Acid/ε-Polylysine Hydrogel with Self-Healing and Antibacterial Properties for Wound Healing

Although pyroelectric photodetectors have been intensively studied, the transient temperature change rate of pyroelectric materials is a main restrictive factor for improving the performance. In this work, we fabricate an ultrafast response self-powered near-infrared (NIR) photodetector (PD) based on Au nanoparticles (NPs) coated an n-ZnO nanowires (NWs)/p-Si heterojunction. The local surface plasmon resonance (LSPR) effect generated at the local contacts of Au NPs/ZnO NWs can significantly enhance the transient temperature change rate of the ZnO material to improve the photoresponse performances of the NIR PD. Compared with that in the pristine ZnO-based PD, the response time of the Au-coated NIR PD is decreased from 113 to 50 μs at the rising edge and 200 to 70 μs at the falling edge. Optical responsivity and detectivity of the Au-coated ZnO-based PD are increased by 212 and 266%, respectively. The pyroelectric current gain is produced by injecting hot electrons from the LSPR effect of Au NPs into the ZnO material and the thermal energy transfer caused by the photothermal effect of plasmonic Au nanostructure. This work provides an in-depth understanding of plasmonic effect-enhanced pyroelectric effect and presents a unique strategy for developing high-performance NIR photodetectors.

Yifan Wang

Yu Zhu

Huaimin Gu

Xingfu Wang

Enhanced Performances of n-ZnO Nanowires/p-Si Heterojunctioned Pyroelectric Near–Infrared Photodetectors via the Plasmonic Effect

MXene sheets, as new 2D nanomaterials, have been used in many advanced applications due to their superior thin-layered architecture, as well as their capability to be employed as novel nanocontainers for advanced applications. In this research, intercalated Ti3C2 MXene sheets were synthesized through an etching method, and then they were modified with 3-aminopropyltriethoxysilane (APTES). Cerium cations (Ce3+) as an eco-friendly corrosion inhibitor were encapsulated within Ti3C2 MXene sheets to fabricate novel self-healing epoxy nanocomposite coatings. The corrosion protection performance (CPP) of Ce3+-doped Ti3C2 MXene nanosheets (Ti3C2 MXene-Ce3+) in a 3.5 wt % sodium chloride (NaCl) solution was studied on bare mild steel substrates using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization measurements. The self-healing CPP of epoxy coatings loaded with 1 wt % undoped and doped Ti3C2 MXene was evaluated using EIS, salt spray, and field emission scanning electron microscopy (FE-SEM) techniques. The introduction of Ti3C2 MXene-Ce3+ into the corrosive solution and artificially scribed epoxy coating enhanced the total impedance from 717 to 6596 Ω cm2 and 8876 to 32092 Ω cm2, respectively, after 24 h of immersion compared to the control samples.

Seyyed Arash Haddadi

Shujun Hu

Saeed Ghaderi

Abbas Ghanbari

Mohsen Ahmadipour

Swee-Yong Pung

Shibo Li

Mehrzad Feilizadeh

Mohammad Arjmand

Amino-Functionalized MXene Nanosheets Doped with Ce(III) as Potent Nanocontainers toward Self-Healing Epoxy Nanocomposite Coating for Corrosion Protection of Mild Steel

Pankaj Sharma

Chi-Hou Lei

Yunya Liu

Daniel Sando

Qi Zhang

Nagarajan Valanoor

Jan Seidel

Ferroelectric Domain Wall Warp Memristor

铁电畴壁弯曲忆阻器

Seungwoo Baek

Hyeryeong Lee

Yoo Seok Lee

In Seop Chang

In-Geol Choi

A Redox-Enzyme Integrated Microbial Fuel Cell Design Using the Surface Display System in Shewanella oneidensis MR-1

使用Shewanella oneidensis MR-1表面展示系统设计的氧化还原酶集成微生物燃料电池

Zonglin Jiang

Chen Li

Fei Qi

Zhenbei Wang

Yatao Liu

Fan Li

Hui Wang

Zhaoyong Bian

Mingshan Zhu

J. Kumirska

Ewa Maria Siedlecka

A Review on Photocatalytic Hydrogen Peroxide Production from Oxygen: Material Design, Mechanisms, and Applications

光催化氧气制备过氧化氢的材料设计、机理及应用综述

Biomimetic particles that can replicate aspects of natural biological cell function are useful for advanced biological engineering applications. Engineering such particles requires mimicking the chemical complexity of the surface of biological cells, and this can be achieved by coating synthetic particles with naturally derived cell membranes. Past research has demonstrated the feasibility of utilizing cell membrane coatings from a variety of cell types to achieve extended blood circulation half-life. A particle's shape can also be designed to mimic a biological cell or virus, and this physical attribute can cause particular transport and biodistribution properties. However, the potential synergy between engineering a biomimetic particle's core shape in combination with functionalizing its surface with cell membranes to achieve targeted drug delivery has not been well-investigated. Here, anisotropic poly(lactic-co-glycolic acid) (PLGA) particles are coated with platelet membranes to engineer particles with enhanced stealth properties that are biomimetic in size, shape, and surface composition to natural platelets. The natural ability of platelets to target tumor cells was harnessed to develop a particulate system for targeted dual delivery of a small molecule and protein to cancer cells. The particles had targeted binding to metastatic human breast cancer cells, leading to enhanced killing of these cells in a mouse model through codelivery of TRAIL and doxorubicin. This system can be used for cancer cell killing and could potentially be utilized in preventing breast cancer metastasis. By engineering both the physical and chemical properties of the particles, biomimicry and therapeutic promise can be best achieved.

Hongzhe Yu

Elana Ben-Akiva

Randall A. Meyer

Jordan J. Green

Biomimetic Anisotropic-Functionalized Platelet-Membrane-Coated Polymeric Particles for Targeted Drug Delivery to Human Breast Cancer Cells

仿生各向异性功能化血小板膜包覆聚合物颗粒用于人乳腺癌细胞靶向药物递送

The emergence of resistance in Pseudomonas aeruginosa represents a significant global health challenge, particularly due to the hurdle of effectively penetrating biofilms with antimicrobials. Moreover, the rise of antibiotic-resistant pathogens has driven the urgent need for developing innovative therapeutic approaches to overcome antibiotic resistance. Antibacterial phototherapy strategies have shown great potential for combating pathogens due to their broad-spectrum antimicrobial activity, spatiotemporal controllability, and relatively low rate of resistance emergence. However, due to the lack of bacterial specificity and penetration, photosensitizers cause considerable damage to mammalian cells and normal tissues and are less effective against bacterial biofilms. Herein, we developed a novel dual-targeting antibacterial strategy to construct a near-infrared photosensitizer, Cy-NEO-Leu. Cy-NEO-Leu showed great bacterial targeting affinity, penetrating and accumulating in biofilms. At the site of infection, it was specifically activated by P. aeruginosa aminopeptidase (PaAP), producing Cy-NEO-NH2, which demonstrated outstanding photothermal (PTT) and photodynamic (PDT) properties, with a photothermal conversion efficiency of up to 70.34%. Both in vitro and in vivo results demonstrated that Cy-NEO-Leu significantly reduced the biofilm biomass and bacterial viability in P. aeruginosa biofilms. Moreover, phototherapy with Cy-NEO-Leu further activated the immune system, enhancing therapeutic efficacy and promoting wound healing. RNA-seq analysis revealed that the antibacterial mechanism of Cy-NEO-Leu-mediated phototherapy involves disruption of the transcriptional and translational processes of P. aeruginosa under laser irradiation. Overall, our results present a promising therapeutic approach against P. aeruginosa biofilms and inspire the development of next-generation antimicrobials.

Yang Liu

Kaixuan Liu

Ling lei

Qinghua Wang

Xiang Wang

Xiangchuan Meng

Qian Liu

Jiacheng Du

Leilei Zhang

Marc Nazaré

Hai-Yu Hu

Aminopeptidase-Responsive NIR Photosensitizer for Precision Targeting and Eradication of Pseudomonas aeruginosa Biofilms

氨基肽酶响应型近红外光敏剂用于精准靶向和清除铜绿假单胞菌生物膜

Abbreviation	ACS Appl. Mater. Interfaces
Journal Impact	8.19
Quartiles(Global)	NANOSCIENCE & NANOTECHNOLOGY(Q1)

ISSN	1944-8244, 1944-8252
h-index	311
Top Journals	Yes

Publication Information	Publisher: American Chemical Society，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2009，Proportion of original research papers: 99.27%，Self Citation Rate:4.80%， Gold OA Rate: 6.13%
Average review cycle	网友分享经验：平均1.9个月
Average recruitment ratio	网友分享经验：78%

ACS Applied Materials and Interfaces

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