The journal ACS Synthetic Biology is particularly interested in the design and synthesis of new genetic circuits and gene products, computational methods in systems design, and integrative approaches to understanding diseases and metabolism. Topics may include, but are not limited to: design and optimization of genetic systems, principles of genetic circuit design and their organization, computational methods supporting genetic system design, quantitative experimental methods for genetic components, circuit and metabolic flux, creation, analysis, and ontological representation of gene component libraries, protein engineering (including computational design), metabolic engineering and cell manufacturing (including biomass conversion), acquisition, engineering, and production of natural products, creative and innovative applications of cell programming, medical applications, tissue engineering and programmed therapy, design and construction of minimal cells, genomics and genomic replacement strategies, viral engineering, automation and robotic assembly platforms for synthetic biology, DNA synthesis methods, metagenomics and synthetic metagenomics analysis, bioinformatics applications in gene discovery, cheminformatics and pathway construction, gene optimization, genome-scale measurement methods for transcriptomics and metabolomics, as well as systems biology and methods for integrating multiple data sources, in vitro and cell-free synthetic biology, molecular programming, and nucleic acid engineering.