该杂志将涵盖生物​​学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业。具有临床意义和意义的文章将被优先考虑。

The Asian Pacific Journal of Tropical Biomedicine covers a wide range of fields including biology, bacteriology, biochemistry, biotechnology, cell biology, environmental biology, microbiology, medical microbiology, pharmacology, physiology, pathology, immunology, virology, toxicology, epidemiology, vaccinology, hematology, histopathology, cytology, genetics, and tropical agriculture. Articles with clinical significance and importance will be given priority.

《Asian Pacific Journal of Tropical Biomedicine》涵盖生物学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业等领域。具有临床意义和重要性的文章将优先考虑。

Asian Pacific Journal of Tropical Biomedicine

Emerging viruses are viruses whose occurrence has risen within the past twenty years, or whose presence is likely to increase in the near future. Diseases caused by emerging viruses are a major threat to global public health. In spite of greater awareness of safety and containment procedures, the handling of pathogenic viruses remains a likely source of infection, and mortality, among laboratory workers. There is a steady increase in both the number of laboratories and scientist handling emerging viruses for diagnostics and research. The potential for harm associated to work with these infectious agents can be minimized through the application of sound biosafety concepts and practices. The main factors to the prevention of laboratory-acquired infection are well-trained personnel who are knowledgable and biohazard aware, who are perceptive of the various ways of transmission, and who are professional in safe laboratory practice management. In addition, we should emphasize that appropriate facilities, practices and procedures are to be used by the laboratory workers for the handling of emerging viruses in a safe and secure manner. This review is aimed at providing researchers and laboratory personnel with basic biosafety principles to protect themselves from exposure to emerging viruses while working in the laboratory. This paper focuses on what emerging viruses are, why emerging viruses can cause laboratory-acquired infection, how to assess the risk of working with emerging viruses, and how laboratory-acquired infection can be prevented. Control measures used in the laboratory designed as such that they protect workers from emerging viruses and safeguard the public through the safe disposal of infectious wastes are also addressed.

I. Made Artika

Chairin Nisa Ma'roef

Laboratory biosafety for handling emerging viruses

实验室处理新发病毒的生物安全

The Clp/Hsp100 family, part of the ATPase associated with various cellular activities (AAA+) superfamily, includes caseinolytic peptidase B (ClpB), a highly conserved protein found in bacteria, fungi, protozoa, and plants. Notably, ClpB is present in all ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter spp. ClpB plays a crucial role in reactivating and disaggregating proteins, enabling pathogens to survive under host-induced stress and conferring thermotolerance to bacterial cells. Infections caused by ESKAPE pathogens are particularly challenging due to their resistance to broad-spectrum antibiotics and biofilm formation, posing a significant global health threat as they are often multidrug-resistant, extensively drug-resistant, and pan-drug-resistant. Given its absence in human cells and its essential role in bacterial survival under stress, ClpB is a promising target for antimicrobial therapy. Targeting Hsp100 family proteins could lead to the development of novel antifungal and antiprotozoal treatments. This review explores the function of ClpB in the survival of ESKAPE pathogens and the protozoan Plasmodium falciparum . Relevant research findings were compiled using academic databases, and data analysis was performed using Clustal Omega Multiple Sequence Alignment and Boxshade tools.

Sachini J. Udari

Sayoka Shamodhi

Rumesh M. Nelumdeniya

Udayana Ranatunga

Nimesha N. Senadeera

Chathuranga B. Ranaweera

ClpB chaperone as a promising target for antimicrobial therapy: A narrative review

ClpB分子伴侣作为抗菌疗法的有前景靶点：一项叙述性综述

Objective: To evaluate the effect of Grifola frondosa polysaccharides (GFP) in a rat model of Alzheimer’s disease (AD). Methods: Seventy-five rats were divided into five groups: the normal control group and the AD group treated with or without GFP (100, 200, and 400 mg/kg). Behavioral responses in the open field test and elevated plus maze test were assessed. Additionally, the levels of malondialdehyde and ferric-reducing ability of plasma, and the mRNA expressions of TNF -α, IL-6 , and IL-1β in the hippocampus were measured. Results: Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test ( P &lt; 0.05). In addition, the level of malondialdehyde and the mRNA expressions of TNF -α, IL -6, and IL-1β were decreased by GFP treatment in a dose-dependent manner in AD rats ( P &lt; 0.05), while the level of ferric-reducing ability of plasma was significantly increased ( P &lt; 0.05). Conclusions: Oral administration of GFP can reduce inflammation and oxidative stress, as well as improve behavioral responses associated with AD, suggesting its potential use in AD treatment. However, additional studies are needed to elucidate its underlying mechanisms and efficacy.

Samira Behrad

Sina Pourranjbar

Mohammad Pourranjbar

Saeid Abbasi-Maleki

Samira Rostami Mehr

Reza Hossein Gholizadeh Salmani

Nasrollah Moradikor

Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

灰树花多糖减轻大鼠阿尔茨海默病症状

Objective: To evaluate the cardioprotective effect of bioassay-guided isolated fractions of Cleome viscosa methanolic extract in streptozotocin-induced diabetic rats. Methods: Total phenolics, flavonoids, and in vitro antioxidant activities of the methanolic extract of Cleome viscosa were evaluated. The FD-40 fraction from this extract was further evaluated for antihyperglycemic efficacy (insulin and HbA1c), antioxidant activity, and cardioprotective effects (creatine kinase-MB, lactate dehydrogenase, and histopathology) in streptozotocin-induced diabetic rats. In silico studies were also conducted to assess the bioactivity of FD-40. Results: Cleome viscosa methanolic extract exhibited the highest antioxidant activity in DPPH, ABTS, H 2 O 2 , and FRAP assays compared to other extracts. Treatment with FD-40 (40 mg/kg b.w.) isolated from this extract normalized blood glucose, insulin, HbA1c, creatine kinase-MB, and lactate dehydrogenase levels in diabetic rats. It also significantly reduced oxidative stress by increasing antioxidant enzymes, decreasing lipid peroxidation as well as restoring the levels of ascorbic acid and glutathione. Histological study demonstrated that FD-40 treatment improved cardiac structure in diabetic rats. Molecular docking analysis revealed that phytocompounds from FD-40 had strong binding affinities with cardiac markers and oxidative enzymes. Hexose (5TMS) demonstrated greater binding affinity with xanthine oxidase and lactate dehydrogenase. Conclusions: FD-40 of Cleome viscosa methanolic extract exhibits significant cardioprotective effects in diabetic rats by regulating cardiac markers and reducing oxidative stress. The underlying mechanisms need to be elucidated in the future.

Suresh Yarrappagaari

Lavanya Thopireddy

Srinivasulu Cheemanapalli

Venkata Ramireddy Narala

Rajeswara Reddy Saddala

Cardioprotective effect of bioassay–guided fractions of Cleome viscosa methanolic extract in streptozotocin–induced diabetic rats

生物活性导向的Cleome viscosa甲醇提取物组分对链脲佐菌素诱导的糖尿病大鼠的心脏保护作用

The rise of emerging infectious diseases has become notably prominent due to ecological changes and mutations in pathogens. The respiratory illness outbreak caused by the COVID-19 pandemic has spread globally. Natural products contain numerous structures and biological activities, offering ample options for discovering new antiviral drugs with unique targets and mechanisms. Andrographis paniculata has been utilized in Indian Ayurvedic, Swedish, Traditional Thai, and Chinese medicine to alleviate coughs, colds, and influenza symptoms. Early-stage laboratory studies indicate that this herbal extract may reduce inflammation and fever, and boost the body’s natural defenses against viruses, potentially leading to symptom relief. This review aims to systematically present clinical trial data about antiviral herbal formulations derived from Andrographis paniculata , delineating the antiviral effects of both natural and synthetic derivatives, along with in silico analyses.

Kumarappan Chidambaram

Antiviral efficacy of Andrographis paniculata and andrographolides: A narrative review

穿心莲和穿心莲内酯的抗病毒功效：叙述性综述

Objective: To elucidate the anti-melanogenic potential of Carex pumila Thunb. extract (FBCC-EP850). Methods: A collection of 180 plant extracts was tested for inhibition of mushroom tyrosinase activity using an in vitro assay. Among them, FBCC-EP850 exhibited the most promising inhibitory activity. Further analysis was conducted to investigate its mechanisms and therapeutic potential in reducing melanogenesis in B16F10 melanoma cells and zebrafish larvae. Results: FBCC-EP850 inhibited mushroom tyrosinase activity in a dose-dependent manner, with a half-maximal inhibitory concentration of 45.83 μg/mL. FBCC-EP850 at concentrations up to 50 pg/mL demonstrated minimal cytotoxicity against B16F10 melanoma cells and no adverse effects on zebrafish larvae. Treatment with 50 μg/mL of FBCC-EP850 significantly reduced α-melanocyte stimulating hormone-induced melanin production and suppressed cellular tyrosinase activity in B16F10 melanoma cells. Additionally, FBCC-EP850 at 25 and 50 μg/mL effectively diminished hyperpigmentation in α-melanocyte stimulating hormone-stimulated zebrafish larvae. Its anti-melanogenic action could be attributed to modulation of the cAMP-CREB-MITF signaling pathway. Conclusions: Carex pumila extract can inhibit melanogenesis by modulating the cAMP-CREB-MITF signaling pathway, which can be used as a promising candidate for treating hyperpigmentation disorders.

Abbreviation	Asian Pac. J. Trop. Biomed.
Journal Impact	1.89
Quartiles(Global)	TROPICAL MEDICINE(Q3)

ISSN	2221-1691, 2588-9222
h-index	81

Publication Information	Publisher: Wolters Kluwer Medknow Publications，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2011，Proportion of original research papers: 87.72%，Self Citation Rate:11.80%， Gold OA Rate: 91.91%
Average review cycle	网友分享经验：4 Weeks

Asian Pacific Journal of Tropical Biomedicine

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Laboratory biosafety for handling emerging viruses

ClpB chaperone as a promising target for antimicrobial therapy: A narrative review

Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

Cardioprotective effect of bioassay–guided fractions of Cleome viscosa methanolic extract in streptozotocin–induced diabetic rats

Antiviral efficacy of Andrographis paniculata and andrographolides: A narrative review

ClpB chaperone as a promising target for antimicrobial therapy: A narrative review

Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

Cardioprotective effect of bioassay–guided fractions of Cleome viscosa methanolic extract in streptozotocin–induced diabetic rats

Antiviral efficacy of Andrographis paniculata and andrographolides: A narrative review

Anti–melanogenic properties of FBCC–EP850 derived from Carex pumila Thunb