检验医学年鉴是韩国检验医学会的官方期刊。期刊名称最近从 2012 年 1 月号的韩国检验医学杂志 (ISSN, 1598-6535) 更改。ANN LAB MED 的 JCR 2017 影响因子为 1.916。

The Annals of Laboratory Medicine is the official journal of the Korean Society of Laboratory Medicine. The journal's name was changed from the Korean Journal of Laboratory Medicine (ISSN: 1598-6535) in the January 2012 issue. The JCR 2017 impact factor of the Annals of Laboratory Medicine is 1.916.

《Annals of Laboratory Medicine》是韩国检验医学会的官方期刊。该期刊的名称于2012年1月号时由《韩国检验医学杂志》（ISSN: 1598-6535）更改而来。《Annals of Laboratory Medicine》的JCR 2017影响因子为1.916。

Annals of Laboratory Medicine

Sun Mi Cho, M.D., Hye Sun Lee, Ph.D., Soyoung Jeon, Ph.D., Yoonjung Kim, M.D., Ph.D., Sun-Young Kong, M.D., Ph.D., Jin Kyung Lee, M.D., and Kyung-A Lee, M.D., Ph.D.. Ann Lab Med 2023;43:605-13. https://doi.org/10.3343/alm.2023.43.6.605

Sun Mi Cho

Hye Sun Lee

Soyoung Jeon

Yoonjung Kim

Sun-Young Kong

Jin Kyung Lee

Kyung-A Lee

Cost-Effectiveness Analysis of Three Diagnostic Strategies for the Detection of <i>EGFR</i> Mutation in Advanced Non-Small Cell Lung Cancer

Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory tests are integral in the management of these conditions. The repertoire of thyroid tests includes blood tests for thyroid-stimulating hormone (TSH), free thyroxine, free triiodothyronine, thyroglobulin (Tg), thyroglobulin antibodies (Tg-Ab), thyroid peroxidase antibodies (TPO-Ab), TSH receptor antibodies (TRAb), and calcitonin. TSH and free thyroid hormone tests are frequently used to assess the functional status of the thyroid. TPO-Ab and TRAb tests are used to diagnose Hashimoto's thyroiditis and Graves' disease, respectively. Tg and calcitonin are important tumor markers used in the management of differentiated thyroid carcinoma and medullary thyroid carcinoma (MTC), respectively. Procalcitonin may replace calcitonin as a biomarker for MTC. Apart from understanding normal thyroid physiology, it is important to be familiar with the possible pitfalls and caveats in the use of these tests so that they can be interpreted properly and accurately. When results are discordant, clinicians and laboratorians should be mindful of possible assay interferences and/or the effects of concurrent medications. In addition, thyroid function may appear abnormal in the absence of actual thyroid dysfunction during pregnancy and in critical illness. Hence, it is important to consider the clinical context when interpreting results. This review aims to describe the above-mentioned blood tests used in the diagnosis and management of thyroid disorders, as well as the pitfalls in their interpretation. With due knowledge and care, clinicians and laboratorians will be able to fully appreciate the clinical utility of these important laboratory tests.

Shui-Boon Soh

Tar-Choon Aw

Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility

Background Millions of patients undergo cardiac surgery each year. The red blood cell distribution width (RDW) could help predict the prognosis of patients who undergo percutaneous coronary intervention or coronary artery bypass surgery. We investigated whether the RDW has robust predictive value for the 30-day mortality among patients in an intensive care unit (ICU) after undergoing cardiac surgery. Methods Using the Medical Information Mart for Intensive Care-IV Database, we retrieved data for 11,634 patients who underwent cardiac surgery in an ICU. We performed multivariate Cox regression analysis to model the association between the RDW and 30-day mortality and plotted Kaplan–Meier curves. Subgroup analyses were stratified using relevant covariates. Receiver operating characteristic (ROC) curves were used to determine the predictive value of the RDWs. Results The total 30-day mortality rate was 4.2% (485/11,502). The elevated-RDW group had a higher 30-day mortality rate than the normal-RDW group (P<0.001). The robustness of our data analysis was confirmed by performing subgroup analyses. Each unit increase in the RDW was associated with a 17% increase in 30-day mortality when the RDW was used as a continuous variable (adjusted hazard ratio=1.17, 95% confidence interval, 1.10–1.25). Our ROC results showed the predictive value of the RDW. Conclusions An elevated RDW was associated with a higher 30-day mortality in patients after undergoing cardiac surgery in an ICU setting. The RDW can serve as an efficient and accessible method for predicting the mortality of patients in ICUs following cardiac surgery.

Weiqiang Chen

Peiling Yu

Chao Chen

Shaoyan Cai

Junheng Chen

Chunqin Zheng

Chaojin Chen

Liangjie Zheng

Chunming Guo

Ann Lab Med

Association Between the Red Blood Cell Distribution Width and 30-Day Mortality in Intensive Care Patients Undergoing Cardiac Surgery: A Retrospective Observational Study Based on the Medical Information Mart for Intensive Care-IV Database

红细胞分布宽度与心脏手术后重症监护患者30天死亡率的关联：基于重症监护医学信息集市-IV数据库的回顾性观察研究

Traditional genetic counseling has focused on the target gene and its natural progress with respect to disease risk. Next-generation sequencing (NGS) can produce information on several genetic variants simultaneously, with different functions and consequences for each. Accordingly, determining the status of the patient or consultant and interpreting sequencing results from many genes can largely increase the complexity of genetic counseling. Moreover, the current environment of big data that can be readily shared via the internet and a ubiquitous network provides many different avenues for which a consultant must handle the traditional principle of genetic counseling in different ways. Thus, further consideration and rethinking of genetic counseling principles are necessary in the era of NGS. In this review, we discuss several aspects of genetic counseling that one can encounter when faced with NGS data.

Mina Yang

Jong-Won Kim

Principles of Genetic Counseling in the Era of Next-Generation Sequencing

下一代测序时代遗传咨询的原则

Samuel Vasikaran, M.D., Subashini C. Thambiah, M.Path., Rui Zhen Tan, Ph.D., and Tze Ping Loh, M.B., B.ch., B.A.O.; APFCB Harmonization of Reference Interval Working Group. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2023.0214

Samuel Vasikaran

Subashini C. Thambiah

Rui Zhen Tan

Tze Ping Loh

The Use of Bone-Turnover Markers in Asia-Pacific Populations

亚太人群中骨转换标志物的应用

Yurong Gu, Ph.D., Yanhua Bi, B.S., Zexuan Huang, B.S., Chunhong Liao, B.S., Xiaoyan Li, Ph.D., Hao Hu, B.M., Huaping Xie, B.M., and Yuehua Huang, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0178

Yurong Gu

Yanhua Bi

Zexuan Huang

Chunhong Liao

Xiaoyan Li

Hao Hu

Huaping Xie

Yuehua Huang

CD69 Expression is Negatively Associated With T-Cell Immunity and Predicts Antiviral Therapy Response in Chronic Hepatitis B

CD69表达与T细胞免疫呈负相关，并可预测慢性乙型肝炎抗病毒治疗反应

John Hoon Rim, M.D., Young-gon Kim, M.D., Sollip Kim, M.D., Rihwa Choi, M.D., Jee-Soo Lee, M.D., Seungman Park, M.D., Woochang Lee, M.D., Eun Young Song, M.D., Soo-Youn Lee, M.D., and Sail Chun, M.D., on behalf of the Pharmacogenetics Guideline Task-Force Team of the Korean Society of Laboratory Medicine. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0572

John Hoon Rim

Young-gon Kim

Sollip Kim

Rihwa Choi

Jee-Soo Lee

Seungman Park

Woochang Lee

Eun Young Song

Soo-Youn Lee

Sail Chun

Clinical Pharmacogenetic Testing and Application: 2024 Updated Guidelines by the Korean Society of Laboratory Medicine

临床药物基因检测与应用：2024年韩国检验医学学会更新指南

Hyun Jin Kim, M.D., Ph.D., Manmyung Kim, Ph.D., Hyunjae Zhang, M.E., Hae Ri Kim, M.D., Ph.D., Jae Wan Jeon, M.D., Ph.D., Yuri Seo, M.D., Ph.D., and Qute Choi, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0304

Hyun Jin Kim

Manmyung Kim

Hyunjae Zhang

Hae Ri Kim

Jae Wan Jeon

Yuri Seo

Qute Choi

Artificial Intelligence in Diagnostics: Enhancing Urine Test Accuracy Using a Mobile Phone–Based Reading System

人工智能在诊断中的应用：利用基于手机的读取系统提高尿检准确性

Background: In 2022, the revised WHO classification and International Consensus Classification (ICC) for myeloid neoplasms were published.We examined the impact of these guidelines on AML diagnoses alongside the 2022 European LeukemiaNet (ELN) recommendations on risk stratification. Methods:We included 450 adult patients with newly diagnosed AML (non-acute promyelocytic leukemia) from the cBioPortal open-source dataset.Diagnoses and risk stratifications were revised based on the new guidelines and compared with the 2017 WHO classification.Survival analyses were performed using Cox regression.Results: Among the patients included, 190 (42.2%) had consistent diagnoses across the three classifications, whereas 225 (50.0%) had inconsistent diagnoses.The two major WHO 2017 subtypes, AML not otherwise specified (AML-NOS) and AML with myelodysplasia-related changes (AML-MRC), were further subdivided according to the WHO 2022 and ICC.The ICC had the highest prognostication power among the three classifications.Subgroup analysis according to the different definitions of myelodysplasia-related AML and the introduction of AML with mutated TP53 (AML-TP53) showed that the differentiation of AML-TP53 was beneficial.The update from ELN 2017 to ELN 2022 resulted in significant transitions in a subset of patients.The updated diagnostic classification and ELN risk stratification (i.e., the ICC and ELN 2022) showed a straightforward relationship.Conclusions: This study presents an integrative comparative analysis of past and current guidelines for AML diagnosis and risk classification based on open-source data.The ICC diagnostic criteria are clinically significant for determining AML prognosis.In line with the changing treatment paradigm for AML, future research is needed to continuously validate diagnostic and risk stratification systems.

Jiwon Yun

Reclassification of Acute Myeloid Leukemia According to the 2022 World Health Organization Classification and the International Consensus Classification Using Open-Source Data

根据2022年世界卫生组织分类和国际共识分类对急性髓系白血病进行重新分类，使用开源数据

Predicting in-hospital cardiac arrest (IHCA) is crucial for potentially reducing mortality and improving patient outcomes. However, most models, which rely solely on vital signs, may not comprehensively capture the patients' risk profiles. We aimed to improve IHCA predictions by combining vital sign indicators with laboratory test results and, optionally, International Classification of Disease-10 block for diagnosis (ICD10BD).

Haeil Park

Chan Seok Park

A Machine Learning Approach for Predicting In-Hospital Cardiac Arrest Using Single-Day Vital Signs, Laboratory Test Results, and International Classification of Disease-10 Block for Diagnosis

一种利用单日生命体征、实验室检测结果和国际疾病分类第十版诊断编码预测住院心脏骤停的机器学习方法

Abbreviation	Ann Lab Med
Journal Impact	3.93
Quartiles(Global)	MEDICAL LABORATORY TECHNOLOGY(Q1)

ISSN	2234-3806, 2234-3814
h-index	47

Publication Information	Publisher: Korean Society for Laboratory Medicine，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2012，Proportion of original research papers: 85.71%，Self Citation Rate:12.50%， Gold OA Rate: 100.00%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：容易

Annals of Laboratory Medicine

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Cost-Effectiveness Analysis of Three Diagnostic Strategies for the Detection of EGFR Mutation in Advanced Non-Small Cell Lung Cancer