The journal "ACS Biomaterials Science and Engineering" focuses on modeling and informatics tools for biomaterials, covering scaling methods to guide biomaterial design, predictive algorithms for structure-function relationships, and biomaterial mechanics. It also explores new biomaterials and bioinspired approaches, including synthesis and chemical modifications, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, and new processing modes to purify and utilize natural polymers. Additionally, the journal addresses biophysical regulation of cell functions, controlled and bioresponsive delivery of regulatory molecules, genetic biomaterials design, synthetic biology, and new composite systems. The interactions between biomaterial interfaces and biology and health are also examined, including material-biology interactions, chemical/morphological/structural communication, signaling and biological responses, health risks, toxicology, safety, calcification, corrosion, and degradation of biomaterials and devices, as well as issues related to prosthetics. Finally, the journal discusses manufacturing, technology, and tissues in the context of biomaterials, including regenerative medicine, tissue engineering for basic and applied studies, organ-on-a-chip, bioreactor/perfusion systems, microdevices, 3D printing, inks, BioMEMS, optics and electronics interfaces with biomaterials, and systems integration.