CURRENT MEDICAL SCIENCE 为医学科学领域的同行评议论文提供论坛，以促进中国研究人员和医生与外国同行之间的学术交流。期刊涵盖生理学、生物化学、分子生物学、药理学、病理学和病理生理学等生物医学学科和外科、内科、妇产科、儿科、耳鼻喉科等临床研究学科。 MEDICAL SCIENCE 以英文为主，极少数论文为德文，以向其德国创始人致敬。本刊是中国中部地区教育机构主办的唯一西文医学期刊。

Current Medical Science is a peer-reviewed journal that provides a forum for papers in the field of medical science, aimed at promoting academic exchange between Chinese researchers and physicians and their international counterparts. The journal covers biomedical disciplines such as physiology, biochemistry, molecular biology, pharmacology, pathology, and pathophysiology, as well as clinical research fields including surgery, internal medicine, obstetrics and gynecology, pediatrics, and otorhinolaryngology. The journal primarily publishes in English, with a very limited number of papers in German, in honor of its German founder. It is the only Western medical journal published by educational institutions in Central China.

《Current Medical Science》是一个为医学科学领域的同行评审论文提供论坛的期刊，旨在促进中国研究人员和医生与国际同行之间的学术交流。该期刊涵盖生理学、生物化学、分子生物学、药理学、病理学和病理生理学等生物医学学科，以及外科、内科、妇产科、儿科、耳鼻喉科等临床研究领域。期刊主要以英文发表，极少数论文为德文，以向其德国创始人致敬。本刊是中国中部地区教育机构主办的唯一西文医学期刊。

Current Medical Science

Developing the methodologies that allow for safe and effective delivery of therapeutic drugs to target sites is a very important research area in cancer therapy. In this study, polyethylene glycol (PEG)-coated magnetic polymeric liposome (MPL) nanoparticles (NPs) assembled from octadecyl quaternized carboxymethyl chitosan (OQC), PEGylated OQC, cholesterol, and magnetic NPs, and functionalized with epithelial growth factor receptor (EGFR) peptide, were successfully prepared for in-vivo liver targeting. The two-step liver targeting strategy, based on both magnetic force and EGFR peptide conjugation, was evaluated in a subcutaneous hepatocellular carcinoma model of nude mouse. The results showed that EGFR-conjugated MPLs not only accumulated in the liver by magnetic force, but could also diffuse into tumor cells as a result of EGFR targeting. In addition, paclitaxel (PTX) was incorporated into small EGFR-conjugated MPLs (102.0±0.7 nm), resulting in spherical particles with high drug encapsulation efficiency (>90%). The use of the magnetic targeting for enhancing the transport of PTX-loaded EGFR-conjugated MPLs to the tumor site was further confirmed by detecting PTX levels. In conclusion, PTX-loaded EGFR-conjugated MPLs could potentially be used as an effective drug delivery system for targeted liver cancer therapy.

Zhen-Lv Lin

Jian Ding

Guo-Ping Sun

Dan Li

Shan-Shan He

Xiao-Fei Liang

Xun-Ru Huang

Jie Xie

Current medical science

Curr Med Sci

Application of Paclitaxel-loaded EGFR Peptide-conjugated Magnetic Polymeric Liposomes for Liver Cancer Therapy.

载紫杉醇的EGFR肽偶联磁性聚合物脂质体在肝癌治疗中的应用。

In this study, the response of Dectin-1 on macrophages to Fusarium solani (F. solani) and the expression patterns of Dectin-1 in experimentally F. solani-induced keratomycosis were investigated. Peritoneal macrophages isolated after intraperitoneal injection of sodium thioglycollate were co-cultured with laminarin and spores of F. solani for 12 h. The expression levels of Dectin-1 and CARD9 were detected by immunofluorescence and real-time quantitative polymerase chain reaction. A mouse model of fungal keratitis was established by substromal inoculation with spores of F. solani. Corneal lesions and inflammatory responses were observed by slit-lamp and histopathology at 1, 2, 3, 5, and 7 day(s) after infection. Dectin-1 expression was significantly upregulated on macrophages stimulated by spores of F. solani. Dectin-1 was not detected in normal corneas of C57BL/6 mice, but detected in infected corneas from the first day after inoculation, with high mRNA levels observed on days 2 and 3. CARD9, a key transducer of Dectin-1 signaling, was also upregulated in infected corneas. In conclusion, Dectin-1 is an important recognition receptor in F. solani-induced keratitis, but the molecular mechanisms warrant further investigation.

Ling-Juan Xu

Li-Xin Xie

Fusarium solani Activates Dectin-1 in Experimentally Induced Keratomycosis.

镰刀菌属激活实验性诱导角膜真菌病中的Dectin-1。

Kai-kai Guo

Chang-ya Liu

Gao-hui Li

Jian-ping Xiang

Xiao-chang Leng

Yi-ke Cai

Xue-bin Hu

Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

前循环分叉与侧壁动脉瘤形态学和血流动力学参数的差异与相关性

Respiratory syncytial virus (RSV) infection is the primary cause of respiratory disease in infants. The formalin-inactivated RSV (FI-RSV) vaccine resulted in an enhanced respiratory disease (ERD) in infants upon natural RSV infection, which is a major obstacle for development of safe and efficacious vaccines. Excessive and uncontrolled Th immune responses could be involved in the ERD. Agonists of TLRs are used as adjuvants to guide the type of immune response induced by vaccines. We evaluated the impact of lipopolysaccharide (LPS), the agonist of TLR4, on ERD as the adjuvant of FI-RSV. The results showed that LPS remarkably inhibited FI-RSV-enhanced lung inflammation, mucus production, airway inflammatory cell infiltration, and inflammatory cytokines following RSV challenge. Interestingly, LPS inhibited both Th2 and Th17 type cytokines in lungs of FI-RSV-immunized mice following RSV challenge, without an increase in the Th1 type cytokines, suggesting a controlled immune response. In contrast, Pam3Cys and Poly(I:C), the agonist of TLR1/2 or TLR3, partly inhibited FI-RSV-enhanced lung inflammation. Pam3Cys inhibited Th17 type cytokine IL-17, but promoted both Th1 and Th2 type cytokines. Poly(I:C) inhibited Th2 and Th17 type cytokines, but promoted Th1 type cytokines. In addition, LPS promoted IgG and IgG2a antibody production, which might provide protection from RSV challenge. These results suggest that LPS inhibits ERD without impairment in antibody production and protection, and the mechanism appears to be related with regulation of Th responses induced by FI-RSV.

Wei Yin

Hong-Yong Li

Bo-Yang Zheng

Yu-Qing Deng

Wen-Jian Li

Ying Liu

Rui-Hong Zeng

Lipopolysaccharide Inhibits FI-RSV Vaccine-enhanced Inflammation Through Regulating Th Responses.

脂多糖通过调节Th反应抑制FI-RSV疫苗增强的炎症。

The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation. Autophagy is a catabolic process responsible for maintaining cellular homeostasis. In recent years, autophagy has been demonstrated to play an important role in neuroinflammation. Resolvin D1 (RvD1) is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving activities. However, whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further investigation. The present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding pathways.

Shang-Wen Pan

Li-Sha Hu

Han Wang

Rui-Ting Li

Ya-Jun He

You Shang

Zhong-Liang Dai

Li-Xin Chen

Wei Xiong

Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells.

Resolvin D1 在BV-2小胶质细胞中诱导mTOR非依赖性和ATG5依赖性的自噬。

There are several types of brain tumors but glioblastoma (GBM) is one of the highly malignant tumors. A primary concern with GBM is that the treatment is inadequate. Even after giving many multi-stacked combinations of therapies to patients, inclusive of chemotherapy, radiation, and surgery, the median survival rate remains poor. Due to its heterogeneous nature, the use of selective therapy for specific targeting of tumor cells is of particular importance. Although many treatment alternatives which include surgery with adjuvant chemotherapy and radiotherapy are available, the prognosis of the disease is very poor. Combination therapy is becoming the foundation of modern antitumor therapy and it is continuously evolving and developing innovative drug regimens as evidenced by ongoing preclinical and clinical trials. In this review, we discuss the current treatment options and emerging therapeutic approaches for the treatment of GBM. The prospects for alternative glioblastoma therapy are also discussed.

Megha Gautam

Reema Gabrani

Current Combinatorial Therapeutic Aspects: The Future Prospect for Glioblastoma Treatment

当前组合治疗方面：胶质母细胞瘤治疗的未来展望

Hepatocellular carcinoma (HCC) presents substantial genetic and phenotypic diversity, making it challenging to predict patient outcomes. There is a clear need for novel biomarkers to better identify high-risk individuals. Long non-coding RNAs (lncRNAs) are known to play key roles in cell cycle regulation and genomic stability, and their dysregulation has been closely linked to HCC progression. Developing a prognostic model based on cell cycle-related lncRNAs could open up new possibilities for immunotherapy in HCC patients.

Lin Chen

Guo-Zhi Wu

Tao Wu

Hao-Hu Shang

Wei-Juan Wang

David Fisher

Nguyen Thi Thu Hiens

Erkin Musabaev

Lei Zhao

Cell Cycle-Related LncRNA-Based Prognostic Model for Hepatocellular Carcinoma: Integrating Immune Microenvironment and Treatment Response

基于细胞周期相关长链非编码RNA的肝细胞癌预后模型：整合免疫微环境和治疗反应

Cystic fibrosis (CF) is a hereditary disorder characterized by mutations in the CFTR gene, leading to impaired chloride ion transport and subsequent thickening of mucus in various organs, particularly the lungs. Despite significant progress in CF management, current treatments focus mainly on symptom relief and do not address the underlying genetic defects. Stem cell and gene therapies present promising avenues for tackling CF at its root cause. Stem cells, including embryonic, induced pluripotent, mesenchymal, hematopoietic, and lung progenitor cells, offer regenerative potential by differentiating into specialized cells and modulating immune responses. Similarly, gene therapy aims to correct CFTR gene mutations by delivering functional copies of the gene into affected cells. Various approaches, such as viral and nonviral vectors, gene editing with CRISPR-Cas9, small interfering RNA (siRNA) therapy, and mRNA therapy, are being explored to achieve gene correction. Despite their potential, challenges such as safety concerns, ethical considerations, delivery system optimization, and long-term efficacy remain. This review provides a comprehensive overview of the current understanding of CF pathophysiology, the rationale for exploring stem cell and gene therapies, the types of therapies available, their mechanisms of action, and the challenges and future directions in the field. By addressing these challenges, stem cell and gene therapies hold promise for transforming CF management and improving the quality of life of affected individuals.

Disha D. Shah

Mehul R. Chorawala

Aanshi J. Pandya

Nirjari Kothari

Bhupendra G. Prajapati

Priyajeet S. Parekh

Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene Therapy Insights

推进对抗囊性纤维化的战斗：干细胞与基因治疗的启示

This study aimed to investigate the incidence and predictors of non-variceal upper gastrointestinal bleeding (NVUGIB) in hospitalized patients with coronavirus disease 2019 (COVID-19), as well as the inpatient outcomes associated with this complication.

Mohammad Aldiabat

Wesam Aleyadeh

Taimur Muzammil

Kemi Adewuyi

Majd Alahmad

Ahmad Jabri

Laith Alhuneafat

Yassine Kilani

Saqr Alsakarneh

Mohammad Bilal

Rates, Risk Factors, and Outcomes of Nonvariceal Upper Gastrointestinal Bleeding in Patients Hospitalized for COVID-19 in the United States

美国住院COVID-19患者非静脉曲张性上消化道出血的发生率、危险因素及结局

Lin Jin

Ying Yu

Peng Miao

Yi-hao Huang

Shu-qing Yu

Ke-fang Guo

Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial

连续竖脊肌平面阻滞对微创心脏手术患者术后恢复的影响：一项前瞻性随机对照临床试验

Abbreviation	Curr. Med. Sci.
Journal Impact	1.88
Quartiles(Global)	MEDICINE, RESEARCH & EXPERIMENTAL(Q3)

ISSN	2096-5230, 2523-899X
h-index	39

Publication Information	Publisher: Huazhong University of Science and Technology，Publishing cycle: 6 issues per year，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2018，Proportion of original research papers: 96.53%，Self Citation Rate:5.00%， Gold OA Rate: 10.99%

Current Medical Science

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