Chemistry—A European Journal is a truly international journal with top quality contributions (2017 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields.

Chemistry (Switzerland) is a truly international journal that publishes high-quality contributions from all areas of chemistry and related fields (2017 ISI Impact Factor: 5.16). It features a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications.

《Chemistry (Switzerland)》是一份真正国际化的期刊，发表来自化学及相关领域的高质量研究成果（2017年ISI影响因子：5.16）。期刊涵盖广泛的内容，包括优秀的综述、迷你综述、概念文章、完整论文和通讯。

Chemistry (Switzerland)

This study presents a critical review of the experimental vapor-liquid equilibrium (VLE) data for the quaternary acetic acid-ethanol-ethyl acetate-water system and its subsystems that are reported in the literature. The thermodynamic consistency of the VLE data were verified using two integral tests: the Redlich–Kister test and the direct integration of the Gibbs–Duhem equation. The VLE data were correlated using the NRTL equation for further integration. Additionally, the reliable value of the integral derived from the direct integration of the Gibbs–Duhem equation for multicomponent systems under isothermal-isobaric conditions was estimated. This integral can be used for testing the thermodynamic consistency of experimental VLE data.

Georgii Misikov

Maya Trofimova

Igor Prikhodko

Chemistry

Vapor-Liquid Equilibrium in the Acetic Acid-Ethanol-Ethyl Acetate-Water Quaternary System: Critical Literature Review and Thermodynamic Consistency of the Experimental Data

醋酸-乙醇-乙酸乙酯-水四元体系中的汽液平衡：关键文献综述与实验数据的热力学一致性

This paper studies the catalytic hydrogenation reduction of lignin-derived phenolic compounds, such as catechol, guaiacol (O-methoxyphenol), phenol, P-methylphenol, O-ethylphenol, O-ethoxyphenol, etc. The reaction system focuses on the catalytic performance of hydrodeoxygenation reactions involving the phenolic derivatives of the lignin depolymerization products catechol and guaiacol. A series of Al2O3-TiO2 composite oxide supports with different Al/Ti ratios were prepared by a co-precipitation method, and a 5% Pd/Al2O3-TiO2 bifunctional catalyst was prepared by an impregnation method and characterized with XRD, SEM, BET, NH3-TPD, etc. Among these, the Pd/Al2Ti1 catalyst had the most excellent catalytic performance. At 100 °C and 2 MPa hydrogen pressure, the conversion of catechol was as high as 100%, and at 100 °C and 5 MPa hydrogen pressure, the conversion of guaiacol reached 90%.

Yumeng Song

Ping Chen

Hui Lou

Xiaoming Zheng

Xiangen Song

Efficient Catalytic Hydrogenation of Lignin-Derived Phenolics Under Mild Conditions

温和条件下木质素衍生酚类的高效催化加氢

The utilization of dodecaborate boron clusters, [B12X12]2− (X = Cl, Br, or I), as membrane carriers has been demonstrated recently, and their activity is known to be due to their superchaotropic nature. In this work, the mono-alkylation of [B12Br11OH]2− to functionalize it with an aliphatic spacer was developed with a view to expanding the known chemical space of membrane carriers based on [B12Br12]2−. A new and improved facile route for the preparation of [B12Br11OH]2−, which is an important precursor to other [B12Br11OR]2− species, is reported. Various alkoxylated [B12Br11O(CH2)5Z]2− (Z = OH, N(CO)2C6H4, CN and N3) derivatives were prepared via a divergent synthesis based on [B12Br11O(CH2)5Br]2−. One of the newly synthesized compounds was utilized as a membrane carrier, and its impact on cell viability was examined.

Satoshi Yamamoto

Hibiki Nakamura

Yumiko K. Kawamura

Taro Kitazawa

Mutsumi Kimura

Yu Kitazawa

Alkoxy Substituted Brominated closo-Dodecaborates with Functionalized Aliphatic Spacers

烷氧基取代的溴化closo-十二硼烷与功能化脂肪族间隔基

Cholinesterases are enzymes that break down the neurotransmitter acetylcholine in the nervous system. The two main types are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE inhibitors are used to treat Alzheimer’s disease by increasing acetylcholine levels. BChE activity increases in later stages of Alzheimer’s, suggesting it might contribute to the disease. In previous experiments, it was found that a newly designed hybrid of galantamine (GAL) and curcumin (CCN) (compound 4b) decreases the activity of BChE in murine brain homogenates. Here, we explore this observation using molecular dynamics simulations. GAL and CCN were also studied for comparison. The structures of the complexes between the BChE and the ligands were predicted by molecular docking. Then, molecular dynamics simulations were performed to evaluate the stability of the complexes and the interactions between the ligands and the enzyme over a simulated time of 1 μs. All three ligands formed stable complexes with BChE. Compound 4b formed more hydrogen bonds and other interactions with BChE compared to GAL and CCN, suggesting a stronger binding affinity. The stronger binding of 4b to BChE might explain its superior anti-BChE activity observed in previous experiments.

Evdokiya Salamanova

Mariyana Atanasova

Irini Doytchinova

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

一种新型加兰他敏-姜黄素杂化物抑制丁酰胆碱酯酶：分子动力学研究

Tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2) are important DNA repair enzymes that remove various adducts from the 3′- and 5′-ends of DNA, respectively. The suppression of the activity of these enzymes is considered as a promising adjuvant therapy for oncological diseases in combination with topoisomerase inhibitors. The simultaneous inhibition of TDP1 and TDP2 may result in greater antitumor effects, as these enzymes can mimic each other’s functions. We have previously shown that usnic acid-based sulfides can act as dual inhibitors, with TDP1 activity in the low micromolar range and their TDP2 at 1 mM. The oxidation of their sulfide moieties to sulfoxides led to an order of magnitude decrease in their cytotoxicity potential, while their TDP1 and TDP2 activity was preserved. In this work, we synthesized new series of usnic acid-based sulfides and their oxidized analogues, i.e., sulfoxides and sulfones, to systematically study these irregularities. The new compounds inhibit TDP1 with IC50 values (the concentration of inhibitor required to reduce enzyme activity by half) in the 0.33–25 μM range. Most sulfides and some sulfoxides and sulfones inhibit TDP2 with an IC50 = 138−421 μM. In addition, the most active compounds synergized (×4) with topotecan on the HeLa cell line as well as causing dose-dependent DNA damage, as confirmed by Comet assay. Sulfides with the 6-methylbenzoimidazol-2-yl substituent (8f, IC50 = 0.33/138 μM, TDP1/2) and sulfones containing a pyridine-2-yl fragment (12k, IC50 = 2/228 μM, TDP1/2) are the most potent derivatives and, therefore, are promising for further development.

Aleksandr S. Filimonov

Marina A. Mikhailova

Nadezhda S. Dyrkheeva

Irina A. Chernyshova

Tatyana E. Kornienko

Konstantin A. Naumenko

Rashid O. Anarbaev

Andrey A. Nefedov

Chigozie Achara

Anthony D. M. Curtis

Olga A. Luzina

Konstantin P. Volcho

Nariman F. Salakhutdinov

Olga I. Lavrik

Jóhannes Reynisson

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

松香酸的硫化物、亚砜和砜衍生物作为人TDP1和TDP2酶的抑制剂

Aqueous two-phase systems (ATPSs) have long been used for the facile and rapid extraction of biomolecules of interest. Selective partitioning of DNA is useful for nucleic acid purification and in the design of novel sensing technologies. This paper investigates the partitioning of a plasmid within a poorly understood ATPS comprising the polymers poly(ethylene glycol) (PEG) 35 kDa and Ficoll 400 kDa. The focus is placed on dissecting the compositional effects of the ATPS—that is, whether set concentrations of physiological ions or the polymers themselves can tune DNA phase preference and strength of partitioning. The work here uncovers the antagonistic effects of magnesium and ammonium ions, as well as the role that phase-forming polymer partitioning plays in plasmid enrichment. Testing the ions in conjunction with different ATPS formulations highlights the complexity of the system at hand, prompting the exploration of DNA’s conformational changes in response to polymer and salt presence. The work presented here offers multiple optimization parameters for downstream applications of PEG–Ficoll ATPSs, such as in vitro transcription/translation-based biosensing, in which performance is heavily dependent upon nucleic acid partitioning.

Tasdiq Ahmed

Adya Verma

Alexandra T. Patterson

Mark P. Styczynski

Shuichi Takayama

Compositional Dependence of DNA Partitioning in a Poly(Ethylene Glycol)–Ficoll Aqueous Two-Phase System

聚乙二醇-菲科尔水相双相系统中DNA分配的组成依赖性

Abbreviation	Chemistry
Journal Impact	2.49
Quartiles(Global)	CHEMISTRY, MULTIDISCIPLINARY(Q3)

ISSN	2624-8549
h-index	14

Publication Information	Publisher: Multidisciplinary Digital Publishing Institute (MDPI)，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2019，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Journal Fees	$Details
Average review cycle	网友分享经验：11 Weeks

Chemistry (Switzerland)

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Vapor-Liquid Equilibrium in the Acetic Acid-Ethanol-Ethyl Acetate-Water Quaternary System: Critical Literature Review and Thermodynamic Consistency of the Experimental Data

Efficient Catalytic Hydrogenation of Lignin-Derived Phenolics Under Mild Conditions

Alkoxy Substituted Brominated closo-Dodecaborates with Functionalized Aliphatic Spacers

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Compositional Dependence of DNA Partitioning in a Poly(Ethylene Glycol)–Ficoll Aqueous Two-Phase System

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study

Alkoxy Substituted Brominated closo-Dodecaborates with Functionalized Aliphatic Spacers

Efficient Catalytic Hydrogenation of Lignin-Derived Phenolics Under Mild Conditions