Advanced Biology

Global warming and the more frequent occurrence of extremly high temperatures seriously affect crop yields. Heat stress (HS) has become a major environmental factor threatening food security worldwide. Understanding how plants sense and respond to HS is of clear interest to plant scientists and crop breeders. However, it is not trivial to elucidate the underlying signaling cascade, as specific cellular responses (ranging from detrimental to systemic effects) must be disentangled. Plants respond and adapt to high temperatures in many ways. In this review, recent progress in understanding heat signal transduction and the role of histone modifications in regulating the expression of genes involved in HS responses are discussed. The outstanding issues that are crucial for understanding the interactions between plants and HS are also discussed. The study of heat signal transduction mechanisms in plants is essential to facilitate the cultivation of heat-resistant crop varieties.

Jiaoteng Bai

Zeyu Shi

Shuzhi Zheng

The Role of Histone Modifications in Heat Signal Transduction in Plants

组蛋白修饰在植物热信号转导中的作用

Abstract Endometrial injury and intrauterine adhesions are increasingly reported in recent years; however, treatment options remain limited. Intravenous injection of mesenchymal stem cells (MSCs) for endometrium regeneration has limited effectiveness as the retention rate of transplanted cells is low. Hydrogel‐based tissue‐engineered solutions, such as MSC‐seeded bioscaffolds, are reported to increase retention rates; however, a less invasive alternative is still desirable. 560‐µm homogeneous Matrigel microspheres are fabricated, loading them with about 1500 MSCs and injecting them into the injured endometria of rats’ uteri. This minimally invasive procedure is proved to significantly increase endometrium thickness by over onefold after 21 d ( p &lt; 0.0001) and fertility rates from 25% to 75% in impaired and repaired uteri ( p &lt; 0.001), respectively. This study provides a minimally invasive alternative to endometrium repair with the promise to establish a broad‐spectrum technique for MSC transplantation.

Bing Xu

Yuanxiong Cao

Zheng Zheng

Edgar A. Galan

Zhiwei Hu

Jun Ge

Xinhui Xing

Shaohua Ma

Injectable Mesenchymal Stem Cell‐Laden Matrigel Microspheres for Endometrium Repair and Regeneration

用于子宫内膜修复和再生的注射型间充质干细胞负载的Matrigel微球

Circadian rhythm disruption is implicated in the initiation and progression of many diseases, including cancer. External stimuli, such as sunlight, serve to synchronize physiological processes and cellular functions to a 24-h cycle. The immune system is controlled by circadian rhythms, and perturbation of these rhythms can potentially alter the immune response to infections and tumors. The effect of circadian rhythm disruption on the immune response to tumors remains unclear. Specifically, the effects of circadian disruption (CD) on immunosuppressive cell types within the tumor, such as myeloid-derived suppressor cells (MDSCs), are unknown. In this study, a shifting lighting schedule is used to disrupt the circadian rhythm of mice. After acclimation to lighting schedules, mice are inoculated with 4T1 or B16-F10 tumors. Tumor growth is increased in mice housed under circadian disrupting lighting conditions compared to standard lighting conditions. Analysis of immune populations within the spleen and tumor shows an increased accumulation of MDSCs within these tissues, suggesting that MDSC mediated immunosuppression plays a role in the enhanced tumor growth caused by circadian disruption. This paves the way for future studies of the effects of CD on immunosuppression in cancer.

Nathan T. Roberts

Cameron R. MacDonald

Hemn Mohammadpour

Marina P. Antoch

Elizabeth A. Repasky

Circadian Rhythm Disruption Increases Tumor Growth Rate and Accumulation of Myeloid‐Derived Suppressor Cells

昼夜节律紊乱增加肿瘤生长速率和髓源性抑制细胞的积累

Abstract Disruptions in circadian rhythms can occur in healthy aging; however, these changes are more severe and pervasive in individuals with age‐related and neurodegenerative diseases, such as dementia. Circadian rhythm alterations are also present in preclinical stages of dementia, for example, in patients with mild cognitive impairments (MCI); thus, providing a unique window of opportunity for early intervention in neurodegenerative disorders. Nonetheless, there is a lack of studies examining the association between relevant changes in circadian rhythms and their relationship with cognitive dysfunctions in MCI individuals. In this review, circadian system alterations occurring in MCI patients are examined compared to healthy aging individuals while also considering their association with MCI neurocognitive alterations. The main findings are that abnormal circadian changes in rest‐activity, core body temperature, melatonin, and cortisol rhythms appear in the MCI stage and that these circadian rhythm disruptions are associated with some of the neurocognitive deficits observed in MCI patients. In addition, preliminary evidence indicates that interventions aimed at restoring regular circadian rhythms may prevent or halt the progress of neurodegenerative diseases and mitigate their related cognitive impairments. Future longitudinal studies with repeated follow‐up assessments are needed to establish the translational potential of these findings in clinical practice.

Ahmadreza Keihani

Ahmad Mayeli

Fabio Ferrarelli

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

健康老化和轻度认知障碍中的昼夜节律变化

Recurrent implantation failure (RIF) is characterized by the repeated failure of implantation, often linked to impaired endometrial receptivity. This study investigates how granulocyte colony-stimulating factor (G-CSF) promotes endometrial stromal cell decidualization.

Huakun Zhang

Zhengzhong Wu

Ningjie Yang

Shuhua Wu

Jing Fan

Ping Wang

Xuemei Li

Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis

粒细胞集落刺激因子通过STAT3/HOXA10轴增强子宫内膜基质细胞的蜕膜化过程

Abstract Neurosensory circuits of the gastrointestinal tract sense microbial and nutrient changes in the gut; however, studying these circuits in vivo is hindered by invasive techniques and ethical concerns. Here, an in vitro model of enteroendocrine cells (EECs) and calcium reporting enteric neurons (ENs) is established and validated for functional signaling. Both mechanical and sucrose stimulation of co‐cultures increased the percentage of neurons undergoing a calcium flux, indicating an action potential. Neuronal activation is blocked with either a piezo or insulin receptor blocker. At baseline, a flow only stimulus elicited 51.9% of neurons to activate in co‐culture, which is decreased to 15.1% with a piezo blocker. Piezo blocked and sucrose stimulated EECs increased neuronal activation to 43.9%, and an insulin blocker reduced response to 12.4%. Since a cell line is used to model the EEC in the previous experiments, primary rat duodenal epithelium enriched for EECs are also stimulated and found to produced measurable insulin. This work shows the ability of EECs to produce insulin and for ENs to sense insulin. These results inspire further work on how insulin production outside the pancreas effects diabetes, insulin as a neurotransmitter, and exploration of additional nutritional and microbiotic stimuli on enteroendocrine‐to‐neuronal signaling.

Jessica R Snyder

Minhal Ahmed

Sukhada Bhave

Ryo Hotta

Ryan A. Koppes

Allan M. Goldstein

Abigail N. Koppes

Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling

肠内分泌细胞感知蔗糖并通过胰岛素信号改变肠神经元兴奋性

Malaria kills millions of people annually, and it is one of the major causes of preventable mortality in the world. Of the different plasmodium species that induce malaria, Plasmodium falciparum and Plasmodium vivax account for the most severe form of malarial disease in humans. This review focuses on understanding preventive measures, mutation-based disease evolution, malaria-related biomarkers, and potential plant bioactive components for the treatment and management of malaria. The burden of malaria drug resistance has made it necessary for scientists to focus on alternative therapeutics, with particular interests in those involving plant-based bioactive components that could mediate biochemical pathways, consisting of metabolic interactions essential for parasitic inhibition. To avoid artefacts or false positives, these bioactive components from plant sources are further filtered using the "pan-assay-interfering compounds" (PAINS) tool. This review discussed the history of malaria treatment, current treatment options, malaria preventive measures, and challenges associated with current treatment strategies. Additionally, this work discusses the barriers while developing drugs from phytochemicals and the steps needed to accelerate the development of new antimalarial from the lead compounds.

Michael P. Okoh

Maxwell O. Egua

Lukman A. Alli

Damayanthi Dalu

Rohit Gundamaraju

Rajeev K. Singla

Bairong Shen

Unveiling the Potential of Natural Resources‐Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies

揭示自然资源衍生疗法在改善疟疾管理中的潜力：从计算到实验研究

This study investigates the formation and properties of vesicles produced via biocatalytic Polymerization-Induced Self-Assembly (bioPISA) as artificial cells. Methods for achieving size uniformity, including gentle centrifugation and sucrose gradient centrifugation, are explored, and the effects of stirring speed on vesicle morphology is investigated. The internal structure of the vesicles, characterized by a polymer-rich matrix, is analyzed using fluorescence correlation spectroscopy (FCS). Additionally, the feasibility of loading macromolecules into pre-formed vesicles is demonstrated using electroporation, and a fluorescent protein as well as enzymes for a cascade reaction were sucesfully incorporated into the fully assembled polymersomes. These findings provide a foundation for developing enzyme-synthesized polymeric vesicles with controlled morphologies for various applications, e.g., in synthetic biology.

Andrea Belluati

Adrian Bloch

Kaloian Koynov

Mariana Müller Nieva

Mohadeseh Bagherabadi

Annette Andrieu‐Brunsen

Harald Kolmar

Nico Bruns

Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

生物PISA中囊泡特性的表征与优化：从尺寸分布到组装后负载

Intrauterine adhesion (IUA) can negatively impact on pregnancy outcomes, leading to reduced pregnancy rates, secondary infertility, and an increased risk of pregnancy complications. Studies have shown that the application of platelet-rich plasma (PRP) in IUA patients is effective. However, the clinical readhesive rate of IUA after treatment is still high, especially in severe cases. Platelet-rich plasma double-network hydrogel (DN gel) is an engineered PRP double network hydrogel, which is a sodium alginate (SA) based PRP hydrogel with egg carton ion cross-linking and fibrin double network. The results of this study show that intrauterine injection of DN gel has a better effect on promoting endometrial regeneration and enhancing endometrial receptivity than PRP gel. The mechanism is analyzed through single-cell sequencing, which may be achieved by increasing the expression of neutrophils (Neut), natural killer cells (NK), and type I classical dendritic cells (cDC1) in the endometrium and inhibiting the infiltration of M2 macrophages. Overall, based on the good healing efficiency and good biocompatibility of DN gel, it is expected to become a method of treating IUA with better efficacy and faster clinical translation.

Zhuomin Wang

Ying Gu

Yiyuan Qu

Xujia Huang

Tao Sun

Wei Wu

Qianyu Hu

Xiao Chen

Yu Li

Huafei Zhao

Yingying Hu

Bingbing Wu

Jian Xu

Prevention of Intrauterine Adhesion with Platelet‐Rich Plasma Double‐Network Hydrogel

富血小板血浆双网络水凝胶预防宫腔粘连

Abbreviation	Adv. Biol. (Weinh).
Journal Impact	3.39
Quartiles(Global)	MATERIALS SCIENCE, BIOMATERIALS(Q3)

ISSN	2701-0198
h-index	37

Publication Information	Publisher: John Wiley & Sons Inc.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2021，Proportion of original research papers: 0.00%，Self Citation Rate:0.00%， Gold OA Rate: 33.18%

Advanced Biology

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The Role of Histone Modifications in Heat Signal Transduction in Plants

Injectable Mesenchymal Stem Cell‐Laden Matrigel Microspheres for Endometrium Repair and Regeneration

Circadian Rhythm Disruption Increases Tumor Growth Rate and Accumulation of Myeloid‐Derived Suppressor Cells

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis

Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling

Unveiling the Potential of Natural Resources‐Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies

Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis

Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

Prevention of Intrauterine Adhesion with Platelet‐Rich Plasma Double‐Network Hydrogel