分子 - 细胞 - 生物医学 - 生理学 - 转化研究 - 系统 - 鼓励假设 BIOESSAYS 是一份经过同行评审、审查和讨论的期刊。我们的目标是在分子、遗传、细胞或生理维度上发表当代生物学的新颖见解、前瞻性评论和评论，并作为这些领域新思想的讨论论坛。另一个目标是鼓励在有机体研究、系统方法和生态系统方面的跨学科和综合生物学，在适当的情况下。

BioEssays is a peer-reviewed journal that focuses on molecular, cellular, biomedical, physiological, translational research, and systems biology. Our aim is to publish novel insights, forward-looking reviews, and comprehensive commentaries in contemporary biology, serving as a forum for discussion of new ideas in these fields. Additionally, we encourage interdisciplinary and integrative biology research in organism studies, systems approaches, and ecosystems where appropriate.

BioEssays 是一本经过同行评审的期刊，专注于分子、细胞、生物医学、生理学、转化研究和系统生物学等领域。我们的目标是发表当代生物学的新颖见解、前瞻性评论和综合评述，并为这些领域的新思想提供讨论平台。此外，我们还鼓励在有机体研究、系统方法和生态系统方面的跨学科和综合生物学研究。

BioEssays

As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co‐morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the ‘gut‐skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut‐skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.

Catherine A. O'Neill

Giovanni Monteleone

John T. McLaughlin

Ralf Paus

The gut‐skin axis in health and disease: A paradigm with therapeutic implications

BioEssaysVolume 41, Issue 1 1800215 Thoughts & Opinion A Perspective on the Potential Utility of a Viscosupplement Multifunctional Biotherapeutic Proteoglycan-4: From mere lubricant to regulator of tissue homeostasis and inflammation James Melrose, James Melrose Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, Australia Sydney Medical School, Northern, The University of Sydney, Sydney, NSW 2052, Australia Faculty of Medicine and Health, The University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, AustraliaSearch for more papers by this author James Melrose, James Melrose Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, Australia Sydney Medical School, Northern, The University of Sydney, Sydney, NSW 2052, Australia Faculty of Medicine and Health, The University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, AustraliaSearch for more papers by this author First published: 30 November 2018 https://doi.org/10.1002/bies.201800215Citations: 2 This article comments on the Hypothesis paper by Nabangshu Das et al., https://doi.org/10.1002/bies.201800166 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume41, Issue1January 20191800215 RelatedInformation

James Melrose

A Perspective on the Potential Utility of a Viscosupplement Multifunctional Biotherapeutic

关于粘弹性补充剂多功能生物治疗潜力的展望

Abstract Mitochondria hold diverse and pivotal roles in fundamental processes that govern cell survival, differentiation, and death, in addition to organismal growth, maintenance, and aging. The mitochondrial protein import system is a major contributor to mitochondrial biogenesis and lies at the crossroads between mitochondrial and cellular homeostasis. Recent findings highlight the mitochondrial protein import system as a signaling hub, receiving inputs from other cellular compartments and adjusting its function accordingly. Impairment of protein import, in a physiological, or disease context, elicits adaptive responses inside and outside mitochondria. In this review, we discuss recent developments, relevant to the mechanisms of mitochondrial protein import regulation, with a particular focus on quality control, proteostatic and metabolic cellular responses, triggered upon impairment of mitochondrial protein import.

Eirini Lionaki

Ilias Gkikas

Nektarios Tavernarakis

Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond

线粒体蛋白输入机制将应激信号传递至细胞质及更远

Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the transcription factor Hypoxia‐inducible factor. In this review we take a look at the emerging evidence for a role for the Warburg effect in the immune and inflammatory responses. The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies.

Eva M. Palsson-McDermott

Luke A. J. O'Neill

The Warburg effect then and now: From cancer to inflammatory diseases

沃伯格效应：从癌症到炎症性疾病

Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double‐stranded RNA (dsRNA) base pairs. However, the criteria for recognizing nonself dsRNAs are rather lenient, and hairpin structure of self‐RNAs can also trigger an immune response. Consequently, aberrant activation of RNA sensors has been reported in numerous human diseases. Yet, in most cases, the activating antigens remain unknown. Recent studies have developed sequencing techniques tailored to specifically capture dsRNAs and identified that various noncoding elements in the nuclear and the mitochondrial genome can generate dsRNAs. Here, the identity of endogenous dsRNAs, their recognition by dsRNA sensors, and their implications in the pathogenesis of human diseases ranging from inflammatory to degenerative are presented.

Sujin Kim

Yongsuk Ku

Jayoung Ku

Yoosik Kim

Evidence of Aberrant Immune Response by Endogenous Double‐Stranded RNAs: Attack from Within

内源性双链RNA引发的异常免疫反应的证据：来自内部的攻击

ABSTRACT Several recently discovered small proteins of less than 100 amino acids control important, but sometimes surprising, steps in the metabolism of cyanobacteria. There is mounting evidence that a large number of small protein genes have also been overlooked in the genome annotation of many other microorganisms. Although too short for enzymatic activity, their functional characterization has frequently revealed the involvement in processes such as signaling and sensing, interspecies communication, stress responses, metabolism, regulation of transcription and translation, and in the formation of multisubunit protein complexes. Cyanobacteria are the only prokaryotes that perform oxygenic photosynthesis. They thrive under a wide variety of conditions as long as there is light and must cope with dynamic changes in the environment. To acclimate to these fluctuations, frequently small regulatory proteins become expressed that target key enzymes and metabolic processes. The consequences of their actions are profound and can even impact the surrounding microbiome. This review highlights the diverse functions of recently discovered small proteins that control cyanobacterial metabolism. It also addresses why many of these proteins have been overlooked so far and explores the potential for implementing metabolic engineering strategies to improve the use of cyanobacteria in biotechnological applications.

Alexander Kraus

Wolfgang R. Hess

How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress

小蛋白如何在胁迫下调节蓝藻的代谢

ABSTRACT Daily rhythms in the rate and specificity of protein synthesis occur in most mammalian cells through an interaction between cell‐autonomous circadian regulation and daily cycles of systemic cues. However, the overall protein content of a typical cell changes little over 24 h. For most proteins, translation appears to be coordinated with protein degradation, producing phases of proteomic renewal that maximize energy efficiency while broadly maintaining proteostasis across the solar cycle. We propose that a major function of this temporal compartmentalization—and of circadian rhythmicity in general—is to optimize the energy efficiency of protein synthesis and associated processes such as complex assembly. We further propose that much of this temporal compartmentalization is achieved at the level of translational initiation, such that the translational machinery alternates between distinct translational mechanisms, each using a distinct toolkit of phosphoproteins to preferentially recognize and translate different classes of mRNA.

Nathan R. James

John S. O'Neill

Circadian Control of Protein Synthesis

蛋白质合成的昼夜节律控制

Abstract The retinal pigment epithelium (RPE) is a specialized epithelium at the back of the eye that carries out a variety of functions essential for visual health. Recent studies have advanced our molecular understanding of one of the major functions of the RPE; phagocytosis of spent photoreceptor outer segments (POS). Notably, a mechanical link, formed between apical integrins bound to extracellular POS and the intracellular actomyosin cytoskeleton, is proposed to drive the internalization of POS. The process may involve a “nibbling” action, as an initial step, to sever outer segment tips. These insights have led us to hypothesize an “integrin adhesome‐like” network, atypically assembled at apical membrane RPE‐POS contacts. I propose that this hypothetical network orchestrates the complex membrane remodeling events required for particle internalization. Therefore, its analysis and characterization will likely lead to a more comprehensive understanding of the molecular mechanisms that control POS phagocytosis.

Ceniz Zihni

Phagocytosis by the retinal pigment epithelium: New insights into polarized cell mechanics

视网膜色素上皮吞噬作用：对极化细胞力学的新见解

ABSTRACT In cancer research, the term epigenetics was used in the 1970s in its modern sense encompassing non‐genetic events modifying the chromatin state, mainly to oppose the emerging oncogene paradigm. However, starting from the establishment of this prominent concept, the importance of these epigenetic phenomena in cancer rarely led to questioning the causal role of genetic alterations. Only in the last 10 years, the accumulation of problematic data, better experimental technologies, and some ambitious models pushed the idea that epigenetics could be at least as important as genetics in early oncogenesis. Until this year, a direct demonstration of epigenetic oncogenesis was still lacking. Now, Parreno, Cavalli and colleagues, using a refined experimental model in the fruit fly Drosophila melanogaster , enforced the initiation of tumors solely by imposing a transient loss of Polycomb repression, leading to a purely epigenetic oncogenesis phenomenon. Despite a few caveats that we discuss, this pioneering work represents a major breakpoint in cancer research. We are led to consider the theoretical and conceptual implications on oncogenesis and to search for links between this artificial experimental model and naturally occurring processes, while revisiting cancer theories that were previously proposed as alternatives to the oncogene‐centered paradigm.

Jean‐Pascal Capp

Benoît Aliaga

Vera Pancaldi

Evidence of Epigenetic Oncogenesis: A Turning Point in Cancer Research

表观遗传性癌发生的证据：癌症研究的一个转折点

The vasculature, present in all tissues, has long been regarded as a mere conduit for oxygen, nutrients, and waste. However, recent research has unveiled endothelial cells as dynamic regulators of tissue homeostasis, capable of influencing organ growth and regeneration through secreted factors called angiocrines [1-4]. The discovery of angiocrines as key mediators of endothelial-parenchymal interactions is transforming our understanding of regenerative medicine and targeted therapies. Follert et al. hypothesize that flow-responsive angiocrines act as central orchestrators of tissue regrowth and regeneration, triggered by mechanical stimuli on endothelial cells following partial organ resection [5]. The currently known liver, lung, and kidney angiocrines are presented with special focus on the recently identified myeloid-derived growth factor (MYDGF) and hepatocyte growth factor (HGF). Different tissues have very different abilities to regenerate after injury or surgical resection. In both mice and humans, the liver exhibits remarkable regenerative capacity, capable of restoring its mass within weeks after losing more than half of its volume, whereas, for example the heart has a very poor regeneration capacity. Compared to the liver, the kidney and lung show limited and delayed compensatory growth, highlighting a spectrum of regenerative potential across organs. Elegant previous experiments have demonstrated that liver regrowth is dependent on angiogenic response and the production of angiocrines, highlighting the crucial role of endothelial cells in the liver growth and regeneration process [6, 7]. To date, several different proteins have been identified as angiocrines produced by the liver endothelial cells with growth-promoting effects. Less is known about angiocrines regulating growth and regeneration in the kidney and lung. Thus, understanding the organ-specific angiocrine signaling during tissue growth, homeostasis, and disease is a key for the development of new therapeutic approaches to maintain organ health and initiate organ renewal. Endothelial cells experience laminar shear stress induced by blood flow, which is presicely adjusted to the physiological needs of each organ. Investigating how flow-responsive angiocrines vary between physiological stresses, such as exercise, and pathological conditions (organ resection or trauma), could unveil distinct regenerative mechanisms. Blood flow, blood pressure, and the amount of mechanical stretching to endothelial cells can rapidly change, for example, in response to acute trauma or heavy exercise. Severe changes in blood flow also occur after partial organ resection, which is the main topic of this hypothesis [5]. The hypothesis also touches upon the pivotal role of angiocrines in tumor progression, suggesting that angiocrines regulate cancer cell behavior and metastasis. Vascular morphology and function are very different in solid tumors compared to healthy tissues, affecting blood flow patterns and mechanoelastic stretch in endothelial cells. Several angiocrines have been shown to influence tumor cell dynamics, but future research should focus on identifying tumor type-specific angiocrines to inform targeted therapies. Understanding tumor-specific angiocrines and their interplay with the tumor microenvironment could pave the way for targeted therapies to inhibit tumor progression Our understanding of endothelial cells and their angiocrine secretome in regulating organ-specific development, maintenance, and regeneration is fast expanding, with vast potential for therapeutic exploration. It is important to note that, in addition to proteins, metabolites or small molecules are also produced and released by endothelial cells. These different types of angiocrines can function locally on adjacent cells or travel through the bloodstream to distant organs, underscoring the complexity and versatility of angiocrine signaling. Future studies will leverage novel single-cell techniques to decode angiocrine diversity across organotypic niches and health states, offering precision interventions for different diseases. This article comments on the hypothesis paper by Paula Follert, Linda Große-Segerath, and Eckhard Lammert, https://doi.org/10.1002/bies.202400207

短名	Bioessays
Journal Impact	3.14
国际分区	BIOLOGY(Q1)
期刊索引	SCI Q2中科院 3 区

ISSN	0265-9247, 1521-1878
h-index	202
国内分区	生物学(3区)生物学生物学(3区)生物学生化与分子生物学(4区)

涉及主题	生物遗传学化学生物化学基因医学细胞生物学内科学进化生物学计算生物学物理
出版信息	出版商: John Wiley & Sons Inc.，出版周期: Monthly，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1984，原创研究文献占比: 67.72%，自引率:0.00%， Gold OA占比: 45.13%
平均审稿周期	网友分享经验：偏慢,4-8周
平均录用比例	网友分享经验：很难

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