​Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.

Alzheimer Disease and Associated Disorders is a peer-reviewed, multidisciplinary journal aimed at clinicians and researchers, with a primary focus on Alzheimer disease and associated disorders. The journal publishes original articles that emphasize research in humans, including epidemiological studies, clinical trials, experimental studies, and investigations into diagnosis and biomarkers, as well as research on the health of individuals with dementia and their caregivers. The scientific content of the journal is complemented by reviews of current literature, discussions of concepts, conjectures, and hypotheses related to dementia, brief reports, and letters to the editor.

《Alzheimer Disease and Associated Disorders》是一本经过同行评审的多学科期刊，面向临床医生和研究人员，主要关注阿尔茨海默病及其相关疾病。该期刊发表原创文章，强调对人类的研究，包括流行病学研究、临床试验和实验研究、诊断和生物标志物的研究，以及对痴呆症患者及其照顾者健康的研究。期刊的科学部分还包括对当前文献的综述、痴呆症相关的概念、推测和假设的讨论、简报和给编辑的信件。

Alzheimer Disease and Associated Disorders

Background: Incidence of dementia increases exponentially with age; little is known about its risk factors in the ninth and 10th decades of life. We identified predictors of dementia with onset after age 85 years in a longitudinal population-based cohort. Methods: On the basis of annual assessments, incident cases of dementia were defined as those newly receiving Clinical Dementia Rating (CDR) ≥1. We used a machine learning method, Markov modeling with hybrid density-based and partition-based clustering, to identify variables associated with subsequent incident dementia. Results: Of 1439 participants, 641 reached age 85 years during 10 years of follow-up and 45 of these became incident dementia cases. Using hybrid density-based and partition-based, among those aged 85+ years, probability of incident dementia was associated with worse self-rated health, more prescription drugs, subjective memory complaints, heart disease, cardiac arrhythmia, thyroid disease, arthritis, reported hypertension, higher systolic and diastolic blood pressure, and hearing impairment. In the subgroup aged 85 to 89 years, risk of dementia was also associated with depression symptoms, not currently smoking, and lacking confidantes. Conclusions: An atheoretical machine learning method revealed several factors associated with increased probability of dementia after age 85 years in a population-based cohort. If independently validated in other cohorts, these findings could help identify the oldest-old at the highest risk of dementia.

Yichen Jia

Chung-Chou H. Chang

Tiffany F. Hughes

Erin Jacobsen

Shu Wang

Sarah B. Berman

M. Ilyas Kamboh

Mary Ganguli

Alzheimer Disease & Associated Disorders

Predictors of Dementia in the Oldest Old

高龄老人痴呆的预测因素

This paper reports findings from a systematic review of the literature on the general public’s knowledge and understanding of dementia/Alzheimer’s disease. The key purpose of the review was to evaluate existing literature with specific attention paid to conceptual and methodological issues and to key findings. Over a 20-year period, 40 published articles satisfied the inclusion criteria. Only 4 of these were qualitative and 5 were cross-national. The review revealed a lack of consistency across studies regarding how knowledge was operationalized, approaches to sampling, response rates, and data collection instruments used including validated scales. A consistent finding across the vast majority of studies was the only fair to moderate knowledge and understanding the general public had. The most common misconception was that dementia was a normal part of aging and there was a lack of clarity about at which point normal age-related memory loss problems become severe enough to indicate dementia. Knowledge of dementia was found to be particularly poor among racial and ethnic minority groups where several myths about causes of dementia were found. Findings point to the need for more educational and advocacy programmes on dementia to be developed particularly in low-income to middle-income countries.

Suzanne Cahill

Maria Pierce

Perla Werner

Andrew Darley

Andrea Bobersky

A Systematic Review of the Public’s Knowledge and Understanding of Alzheimer’s Disease and Dementia

阿尔茨海默病和痴呆症公众知识与理解的系统综述

Purpose: The National Institute of Health Toolbox Cognition Battery (NIHTB-CB) is increasingly used in Alzheimer disease (AD) research. We examined the relation of AD biomarkers with performance in the NIHTB-CB in late middle age. Methods: This is a cross-sectional analysis of 334 Hispanic participants aged 64.22±3.35 years from a study of AD biomarkers. White matter hyperintensities (WMH), infarcts, and cortical thickness in AD regions (CT) were assessed with 3T magnetic resonance imaging. Amyloid and tau were assessed with 18 F-Florbetaben and 18 F-MK6240 positron emission tomography, respectively. Results: Lower CT and infarcts were associated with worse Oral Reading Recognition and Cognition Crystallized Composite scores. Lower CT and higher WMH were associated with worse Pattern Comparison Processing Speed. Amyloid and tau were not associated with any test. Discussion: Amyloid and tau, the culprits of AD, are not related to the NIHTB-CB in late middle age. Continued follow-up will reveal if AD impacts performance on the NIHTB-CB.

Mouna Tahmi

Brady Rippon

Priya Palta

Greysi Sherwood

Gabriela Hernandez

Luisa Soto

Sandino Cespedes

Michelle Pardo

Krystal Laing

Kay Igwe

Aubrey Johnson

Zeljko Tomljanovic

Hengda He

José Gutierrez

Jeanne A. Teresi

Herman Moreno

William Kreisl

Qolamreza Razlighi

Adam M. Brickman

José A. Luchsinger

Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics

晚中年期西班牙裔人群阿尔茨海默病影像学生物标志物与NIH工具箱认知电池表现之间的关系

Background: The potential of Ultra-Ma, an ultrasonic head stimulator, for the supplementary treatment of dementia with Lewy bodies (DLB) was evaluated in patients with various symptoms under poor control by drug therapy. Methods: Patients with DLB treated with choline esterase inhibitor or L-DOPA, either alone or in combination, and who met inclusion criteria were enrolled. Four weeks of placebo stimulation was followed by 8 weeks of active ultrasonic stimulation and a 4-week follow-up. Primary endpoints were the effects of ultrasonic head stimulation on both cognitive dysfunction and behavioral and psychological symptoms of dementia (BPSD). Cognitive dysfunction was evaluated using the Japanese versions of the Mini-Mental State Examination and Montreal Cognitive Assessment, and BPSD was assessed using the Neuropsychiatric Inventory Brief Questionnaire Form. For cognitive fluctuations, the Cognitive Fluctuation Inventory served as an index. Improvements in parkinsonism, activities of daily living, and caregiver burden were examined as secondary endpoints. Results: Twelve patients were enrolled. The primary endpoint was significantly improved during the active stimulation period, as were secondary endpoint ratings for parkinsonism and caregiver burden. No notable adverse events occurred. Conclusions: The findings suggest that ultrasonic head stimulation has supplementary potential when combined with drug treatment in DLB.

Yuta Manabe

Clinical Utility and Safety of an Ultrasonic Head Stimulator in Dementia With Lewy Bodies

路易体痴呆中超声头部刺激器的临床效用和安全性

Background: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group. Methods: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After demonstrating the noninferiority of both treatments, we used combined data for this analysis. Results: The analyzed subpopulation of the per-protocol set groups was balanced (n=126 and 135, respectively). Patient demographics were similar between subgroups. The difference of ADAS-JCOG scores [least-squares mean (95%CI)] between the groups was 0.388 (-0.377 to 1.152, not statistically significant). Conclusion: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.

Yu Nakamura

Takumi Omori

Kenichi Nishiyama

Ichiro Ishikawa

Hiroshi Aoki

Naoki Nagakura

Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease

COVID-19大流行导致的社会隔离对阿尔茨海默病患者认知功能障碍的影响

Introduction: There was limited evidence on the ability of people with Alzheimer disease (AD) to perceive their own emotions. We aimed to compare socioemotional self-perception in persons with mild and moderate AD to their caregivers’ perspective. Method: Cross-sectional assessment of people with mild (n=102) and moderate (n=59) AD and caregivers. Each participant and their caregivers completed the socioemotional questionnaire (SEQ); a 30-item rating scale assessing five dimensions of socioemotional cognition (empathy, emotion recognition, social conformity, antisocial behavior, sociability). We evaluated global cognition, awareness of disease, dementia severity, functionality, neuropsychiatric symptoms, and caregiver burden. Results: Participants in the mild and moderate groups showed a similar pattern of socioemotional self-perception. They differed in the anger domain of the emotion recognition subscale, in the antisocial behavior dimension, and in the sociability subscale. In contrast, the caregivers’ perspective of people with mild and moderate AD showed a significant difference in the emotion recognition domain for fear, disgust, and sadness. There were also significant differences in the empathy subscale for disgust and in the sociability subscale. Cognition was correlated with self-reported reduced perception in social conformity, antisocial behavior, and sociability. Awareness was correlated with emotion recognition, antisocial behavior, and sociability. Neuropsychiatric symptoms were correlated with empathy, emotion recognition, and social conformity. Conclusions: Significant differences were found between caregivers’ perspectives of socioemotional functioning in people with mild and moderate AD. Meanwhile, there were minimal differences in self-perception between the mild and moderate groups.

Rogéria Cristina Rangel da Silva

José Pedro Simões Neto

Tatiana Belfort

Marcia Cristina Nascimento Dourado

Social and emotional self-perception in people with mild to moderate Alzheimer disease compared to caregiver’s perspective in Brazil

巴西轻中度阿尔茨海默病患者的社会情感自我认知与照护者视角的比较

Introduction: Dementia can adversely affect the quality of life (QoL) of family members/partners of those affected. Measuring this often-neglected burden is critical to planning and providing appropriate support services. This study measures this impact using the Family-Reported Outcome Measure (FROM-16). Methods: A large UK cross-sectional online study through patient research platforms, recruited family members/partners of people with dementia, to complete the FROM-16. Results: Totally, 711 family members/partners (mean age=58.7 y, SD=12.5; females=81.3%) of patients (mean age=81.6, SD=9.6; females=66.9) with dementia completed the FROM-16. The FROM-16 mean total score was 17.5 (SD=6.8), meaning “a very large effect” on QoL of family members, with females being more adversely impacted. Conclusions: Dementia profoundly impacts the QoL of family members/partners of patients. Routine use of FROM-16 could signpost provision of care support, reducing family members’ burnout. Such routine data could be used in economic analysis of the burden of dementia as well as in predicting institutionalization.

R. Shah

M.S. Salek

F.M. Ali

S.J. Nixon

K. Otwombe

J.R. Ingram

A.Y. Finlay

Dementia and Its Profound Impact on Family Members and Partners

痴呆症及其对家庭成员和伴侣的深远影响

There is no consensus on how long antidementia medications should be administered to patients with Alzheimer disease (AD). To clarify this issue, we investigated the discontinuation of antidementia medications in Japanese home care settings, including community-dwelling and institutionalized patients. Using medical records from April 2017 to March 2022 at 3 clinics in Tokyo and Chiba prefectures, we selected patients with AD who started receiving home care medicine. Forty-nine patients discontinued antidementia medications during the observation period, there was no apparent deterioration in cognitive function or new occurrence of behavioral and psychological symptoms of dementia caused by the discontinuation of medications. More aggressive discontinuation of AD medications probably is recommended for patients with activities of daily living dysfunction, such as those receiving home care medicine.

Kiwami Kidana

Ryonosuke Yamaga

Hiroko Fujii

Masahiro Akishita

Takashi Yamanaka

Discontinuation of Alzheimer Disease Medications in Patients Receiving Home Care Medicine

家庭护理患者中阿尔茨海默病药物停用的研究

Abbreviation	Alzheimer. Dis. Assoc. Disord.
Journal Impact	1.98
Quartiles(Global)	PATHOLOGY(Q3)

ISSN	0893-0341, 1546-4156
h-index	109

Publication Information	Publisher: Lippincott Williams and Wilkins Ltd.，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1987，Proportion of original research papers: 92.06%，Self Citation Rate:5.60%， Gold OA Rate: 10.27%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：较易

Alzheimer Disease and Associated Disorders

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Predictors of Dementia in the Oldest Old

A Systematic Review of the Public’s Knowledge and Understanding of Alzheimer’s Disease and Dementia

Relationship Between Alzheimer Disease Imaging Biomarkers and Performance on the NIH Toolbox Cognition Battery in Late-middle Age Hispanics

Clinical Utility and Safety of an Ultrasonic Head Stimulator in Dementia With Lewy Bodies

Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease

Clinical Utility and Safety of an Ultrasonic Head Stimulator in Dementia With Lewy Bodies

Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease

Social and emotional self-perception in people with mild to moderate Alzheimer disease compared to caregiver’s perspective in Brazil

Dementia and Its Profound Impact on Family Members and Partners

Discontinuation of Alzheimer Disease Medications in Patients Receiving Home Care Medicine