Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."

Acta Medica is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové, under the Karolinum Press of Charles University. The journal is peer-reviewed and published quarterly in both print and electronic formats. The language of Acta Medica is English, and it includes review articles, original research, brief communications, case reports, announcements, and notices. Founded in 1958, it was originally titled 'A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove.'

《Acta Medica》是由捷克赫拉德茨-克拉洛韦医学院出版的多学科医学期刊，出版单位为查理大学的Karolinum出版社。该期刊经过同行评审，每季度出版一次，提供纸质和电子版。期刊语言为英语，内容包括综述文章、原创研究、简报、病例报告、公告和通知。该期刊创办于1958年，最初名为《查理大学医学院科学著作集》。

Acta Medica

X-linked agammaglobulinemia (XLA) was one of the first inborn errors of immunity to be described. It is caused by pathogenic variants in the gene for Bruton tyrosine kinase (BTK), which has important functions in B cell development and maturation. Recurrent bacterial infections in the first two years of life and hypogammaglobulinemia with absent B cells in male patients are the most common symptoms. A four-month-old male patient underwent surgical removal of urachus persistens complicated with recurrent scar abscesses. Hypogammaglobulinemia (IgG, IgA, and IgM), low phagocytic activity, mild neutropenia, and a normal percentage of B cells were observed in the patient’s immune laboratory profile. Over time, he suffered recurrent respiratory infections (otitis media and rhinosinusitis) and developed B cell depletion, but interestingly, this was with a normalisation of IgG and IgA levels along with undetectable IgM. Molecular-genetic testing confirmed the presence of the pathogenic variant c.1843C&gt;T in the BTK gene, which is associated with a milder phenotype of XLA. Molecular-genetic testing uncovers the variability of clinical and laboratory features of apparently well-known inherited disorders. Patients with mild “leaky” XLA may have normal levels of non-functional or oligoclonal immunoglobulins.

Adam Markocsy

Daniela Kapustová

Andrej Čereš

Eva Froňkova

Miloš Jeseňák

Acta Medica (Hradec Kralove Czech Republic)

Atypical Manifestation of X-linked Agammaglobulinemia – the Importance of Genetic Testing

X连锁无丙种球蛋白血症的非典型表现——遗传检测的重要性

Zirconia ceramics have become popular among other dental ceramics thanks to their biological, mechanical, optical, and aesthetic properties. CAD/CAM (computer-aided design/ computer-aided manufacturing) technology improvement has played a vital role in the increased popularity of zirconia ceramics; easy computer manipulation significantly expanded the possibility of using different types of restorations. Zirconia ceramics have a broad spectrum of indications in prosthetic dentistry, from simple restorations to complex structures supported by dental implants. A good orientation in the classification, features, and manipulation of zirconia ceramics is the main key to success.

Bedirhan Savas Yigit

Marwan Al-Akkad

Radek Mounajjed

Zirconia Ceramics

氧化锆陶瓷

Despite advances in neonatal care, neonatal jaundice remains a common problem in maternity wards. The present retrospective epidemiological study collected data on a sample of 710 newborns and compared the incidence of neonatal jaundice in infants born to Rh (D) negative and 0 Rh (D) positive mothers. The primary aim was to determine whether the higher incidence of maternal alloimmunisation in newborns was causally related to a potentially higher incidence of neonatal jaundice in newborns of 0 Rh (D) positive mothers. To the end, we investigated a possible association between the incidence of neonatal jaundice in 0 Rh (D) positive mothers and the neonatal blood group. The incidence of neonatal jaundice was not found to differ between maternal blood groups. We discuss new preventive measures that may reduce the incidence of neonatal jaundice and thereby reduce the length of hospital stay.

Josef Urbanec

Kateřina Chládková

Magdalena Chvílová Weberová

Sylva Skálová

Jan Kremláček

Neonatal Jaundice: A Study of the Incidence in Children of Rh (D) Negative and 0 Rh (D) Positive Mothers

新生儿黄疸：Rh（D）阴性母亲与0型Rh（D）阳性母亲子女发病率研究

Chronic diarrhea is a significant challenge in clinical practice because of its high prevalence and various causes. Comprehensive clinical assessment and stepwise laboratory approach are crucial for an accurate diagnosis. This report presents a case of an adult woman who experienced chronic watery diarrhea, complicated by renal impairment and multiple electrolyte imbalances, including hypokalemia, hypophosphatemia, and metabolic acidosis. The diagnosis of a vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases was confirmed by elevated serum levels of a vasoactive intestinal polypeptide (VIP) and imaging findings of a pancreatic mass with multiple hepatic lesions. Preoperative management, including fluid rehydration, electrolyte correction, and somatostatin analog therapy, significantly improved her clinical symptoms. Subsequent surgical tumor removal and radiofrequency ablation of the hepatic lesions resulted in complete resolution of symptoms and normalized VIP levels. This case emphasizes the importance of early recognition of this rare tumor in patients with chronic diarrhea to improve clinical outcomes.

Sutharin Suteetorn

Krit Kitisin

Natcha Wanpiyarat

Supaksorn Kunjan

Thiti Snabboon

VIPoma: An Unusual Cause of Chronic Diarrhea

VIPoma：慢性腹泻的罕见病因

All renal transplant recipients should undergo a regular screening for BK viral (BKV) viremia. Gradual reduction of immunosuppression is recommended in patients with persistent plasma BKV viremia for 3 weeks after the first detection, reflecting the presence of probable or suspected BKV-associated nephropathy. Reduction of immunosuppression is also a primary intervention in biopsy proven nephropathy associated with BKV (BKVN). Thus, allograft biopsy is not required to treat patients with BKV viremia with stabilized graft function. There is a lack of proper randomised clinical trials recommending treatment in the form of switching from tacrolimus to cyclosporin-A, from mycophenolate to mTOR inhibitors or leflunomide, or the additive use of intravenous immunoglobulins, leflunomide or cidofovir. Fluoroquinolones are not recommended for prophylaxis or therapy. There are on-going studies to evaluate the possibility of using a multi-epitope anti-BKV vaccine, administration of BKV-specific T cell immunotherapy, BKV-specific human monoclonal antibody and RNA antisense oligonucleotides. Retransplantation after allograft loss due to BKVN can be successful if BKV viremia is definitively removed, regardless of allograft nephrectomy.

Ester Kurašová

Jakub Štěpán

Karel Krejčí

František Mrázek

Pavel Sauer

Jana Janečková

Tomáš Tichý

Current Status, Prevention and Treatment of BK Virus Nephropathy

BK病毒肾病现状、预防与治疗

Edema of the psoas major muscle can indicate various pathologies, such as infection, malignancy, and trauma, but it can also result from benign causes like delayed-onset muscle soreness (DOMS). This article presents the case of a 44-year-old female patient who developed DOMS in the psoas major after participating in an intense abdominal workout. The patient reported hip pain that began a day after the workout, which was confirmed by magnetic resonance imaging (MRI) revealing significant edema in the psoas major muscles, particularly on the right side. Conservative treatment with rest and analgesics led to full recovery within two weeks. DOMS, typically associated with eccentric exercises, can be mistaken for more serious conditions, but its recognition is crucial to avoid unnecessary investigations and interventions. This case highlights the importance of clinical history and imaging findings in distinguishing DOMS from other causes of muscle edema, emphasizing the need for accurate diagnosis to ensure appropriate management.

Laura Gabriela Silva

Victor Sudário Takahashi

José Luiz Masson de Almeida Prado

Henrique Shimidu

Luís Henrique Paiva D'Elia

Márcio Luís Duarte

Delayed-Onset Muscle Soreness of the Psoas Major Muscle Following Abdominal Training: Case Report

腹肌训练后腰大肌延迟性肌肉酸痛病例报告

ISSN	1211-4286, 1805-9694
h-index	32

Publication Information	Publisher: Charles University Faculty of Medicine in Hradec Kralove，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 1996，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：20 Weeks

Acta Medica

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Atypical Manifestation of X-linked Agammaglobulinemia – the Importance of Genetic Testing

Zirconia Ceramics

Neonatal Jaundice: A Study of the Incidence in Children of Rh (D) Negative and 0 Rh (D) Positive Mothers

VIPoma: An Unusual Cause of Chronic Diarrhea

Current Status, Prevention and Treatment of BK Virus Nephropathy

Atypical Manifestation of X-linked Agammaglobulinemia – the Importance of Genetic Testing

Zirconia Ceramics

Neonatal Jaundice: A Study of the Incidence in Children of Rh (D) Negative and 0 Rh (D) Positive Mothers

VIPoma: An Unusual Cause of Chronic Diarrhea

Delayed-Onset Muscle Soreness of the Psoas Major Muscle Following Abdominal Training: Case Report