BIOCHEMIA MEDICA 是克罗地亚医学生物化学和检验医学学会的官方同行评审期刊。该杂志广泛报道了临床化学和检验医学各个方面的研究。以下类别适合该杂志的范围：一般临床化学、血液学和止血、分子诊断和内分泌学。欢迎开发、验证和验证适用于临床化学和检验医学的分析技术和方法，以及涉及实验室组织、自动化和质量控制的研究。该杂志定期发表具有教育意义的分析前案例报告（分析前之谜）、有关应用生物统计学（生物统计学课程）和研究诚信（研究诚信角）的文章。

Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. The journal covers a wide range of research in clinical chemistry and laboratory medicine, including general clinical chemistry, hematology and hemostasis, molecular diagnostics, and endocrinology. We welcome studies on the development, validation, and application of analytical techniques and methods relevant to clinical chemistry and laboratory medicine, as well as research involving laboratory organization, automation, and quality control. Additionally, the journal regularly publishes educational pre-analytical case reports (pre-analytical mysteries), articles on applied biostatistics (biostatistics courses), and discussions on research integrity (research integrity corner).

《Biochemia Medica》是克罗地亚医学生物化学和检验医学学会的官方同行评审期刊。该期刊广泛报道临床化学和检验医学的各个方面，涵盖一般临床化学、血液学与止血、分子诊断和内分泌学等领域。我们欢迎关于适用于临床化学和检验医学的分析技术和方法的开发、验证和应用研究，以及涉及实验室组织、自动化和质量控制的相关研究。此外，该期刊定期发表具有教育意义的分析前案例报告（分析前之谜）、应用生物统计学的文章（生物统计学课程）以及关于研究诚信的讨论（研究诚信角）。

Biochemia Medica

In the clinical laboratory setting, interferences can be a significant source of laboratory errors with potential to cause serious harm for the patient. After hemolysis, lipemia is the most frequent endogenous interference that can influence results of various laboratory methods by several mechanisms. The most common preanalytical cause of lipemic samples is inadequate time of blood sampling after the meal or parenteral administration of synthetic lipid emulsions. Although the best way of detecting the degree of lipemia is measuring lipemic index on analytical platforms, laboratory experts should be aware of its problems, like false positive results and lack of standardization between manufacturers. Unlike for other interferences, lipemia can be removed and measurement can be done in a clear sample. However, a protocol for removing lipids from the sample has to be chosen carefully, since it is dependent on the analytes that have to be determined. Investigation of lipemia interference is an obligation of manufacturers of laboratory reagents; however, several literature findings report lack of verification of the declared data. Moreover, the acceptance criteria currently used by the most manufacturers are not based on biological variation and need to be revised. Written procedures for detection of lipemia, removing lipemia interference and reporting results from lipemic samples should be available to laboratory staff in order to standardize the procedure, reduce errors and increase patient safety.

Nora Nikolac

Lipemia: causes, interference mechanisms, detection and management

血脂异常：病因、干扰机制、检测与管理

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of diabetes. Current methods of DR treatment are predominantly used at advanced stages of the disease and could be associated with serious side effects. Therefore, new diagnostic methods are needed in order to identify the initial stages of DR as well as monitoring the effects of applied therapy. Biochemical biomarkers are molecules found in blood or other biological fluid and tissue that indicate the existence of an abnormal condition or disease. They could be a valuable tool in detecting early stages of DR, identifying patients most susceptible to retinopathy progression and monitoring treatment outcomes. Biomarkers related to DR can be measured in the blood, retina, vitreous, aqueous humour and recently in tears. As the retina represents a small part of total body mass, a circulating biomarker for DR needs to be highly specific. Local biomarkers are more reliable as indicators of the retinal pathology; however, obtaining a sample of aqueous humour, vitreous or retina is an invasive procedure with potential serious complications. As a non-invasive novel method, tear analysis offers a promising direction in further research for DR biomarker detection. The aim of this paper is to review systemic and local inflammatory and angiogenic biomarkers relevant to this sight threatening diabetic complication.

Snježana Kaštelan

Ivana Orešković

Filip Bišćan

Helena Kaštelan

Antonela Gverović Antunica

Biochemia medica

Biochem. med. (Online)

Inflammatory and angiogenic biomarkers in diabetic retinopathy

糖尿病视网膜病变中的炎症和血管生成标志物

Tihana Serdar Hiršl

Koraljka Đurić

Marina Čeprnja

Ivana Zec

Marijana Kraljević Šmalcelj

Tomislav Jukić

Tanja Bobetić-Vranić

Anita Somborac-Bačura

Levothyroxine therapy reduces endocan and total cholesterol concentrations in patients with subclinical hypothyroidism

左旋甲状腺素治疗降低亚临床甲状腺功能减退患者的内皮细胞特异分子和总胆固醇浓度

Petra Andrasic

Renata Zrinski Topic

Ivan Pavic

Jasna Lenicek Krleza

Red blood cell agglutination caused by ceftriaxone and its effect on erythrocyte parameters: a case report

头孢曲松引起的红细胞凝集及其对红细胞参数的影响：一例报告

Slavica Dodig

Ivana Čepelak

Matko Dodig

Are we ready to integrate advanced artificial intelligence models in clinical laboratory?

我们准备好将先进的人工智能模型整合到临床实验室中了吗？

Iva Friščić

Sonja Perkov

Mirjana Mariana Kardum Paro

Understanding green discoloration in serum and citrate plasma samples: a case report

理解血清和枸橼酸血浆样本中的绿色变色现象：病例报告

Lisa Cristelli

Francesca Occhipinti

Daniel Tumiatti

De Luisi Antonia

Erika Jani

Massimo Daves

Implementation of new Westgard rules suggested by the Westgard Advisor software for five immunological parameters

Westgard Advisor软件建议的新Westgard规则在五个免疫学参数中的实施

Abbreviation	Biochem. med. (Online)
Journal Impact	3.65
Quartiles(Global)	MEDICAL LABORATORY TECHNOLOGY(Q1)

ISSN	1330-0962, 1846-7482
h-index	54

Publication Information	Publisher: Biochemia Medica, Editorial Office，Publishing cycle: Semiannual，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2006，Proportion of original research papers: 89.13%，Self Citation Rate:0.00%， Gold OA Rate: 88.37%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：较易

Biochemia Medica

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Lipemia: causes, interference mechanisms, detection and management

Inflammatory and angiogenic biomarkers in diabetic retinopathy

Levothyroxine therapy reduces endocan and total cholesterol concentrations in patients with subclinical hypothyroidism

Red blood cell agglutination caused by ceftriaxone and its effect on erythrocyte parameters: a case report

Are we ready to integrate advanced artificial intelligence models in clinical laboratory?

Levothyroxine therapy reduces endocan and total cholesterol concentrations in patients with subclinical hypothyroidism

Red blood cell agglutination caused by ceftriaxone and its effect on erythrocyte parameters: a case report

Are we ready to integrate advanced artificial intelligence models in clinical laboratory?

Understanding green discoloration in serum and citrate plasma samples: a case report

Implementation of new Westgard rules suggested by the Westgard Advisor software for five immunological parameters