BioMolecular Concepts is a peer-reviewed open access journal fostering the integration of different fields of biomolecular research. The journal aims to provide expert summaries from prominent researchers, and conclusive extensions of research data leading to new and original, testable hypotheses. Aspects of research that can promote related fields, and lead to novel insight into biological mechanisms or potential medical applications are of special interest. Original research articles reporting new data of broad significance are also welcome.    Topics:  -cellular and molecular biology-  genetics and epigenetics-  biochemistry-  structural biology-  neurosciences-  developmental biology-  molecular medicine-  pharmacology-  microbiology-  plant biology and biotechnology.

Biomolecular Concepts is a peer-reviewed open access journal that fosters the integration of various fields of biomolecular research. The journal aims to provide expert summaries from prominent researchers and conclusive extensions of research data that lead to new and original, testable hypotheses. It particularly focuses on research aspects that can promote related fields and offer novel insights into biological mechanisms or potential medical applications. Original research articles reporting new data of broad significance are also welcome. Topics include: - Cellular and Molecular Biology - Genetics and Epigenetics - Biochemistry - Structural Biology - Neurosciences - Developmental Biology - Molecular Medicine - Pharmacology - Microbiology - Plant Biology and Biotechnology.

《Biomolecular Concepts》是一本经过同行评审的开放获取期刊，旨在促进不同生物分子研究领域的整合。该期刊致力于提供来自杰出研究者的专业总结，以及研究数据的结论性扩展，进而形成新的、可验证的假设。特别关注能够促进相关领域研究并为生物机制或潜在医学应用提供新见解的研究方面。同时，欢迎报告具有广泛意义的新数据的原创研究文章。  主题包括：- 细胞与分子生物学 - 遗传学与表观遗传学 - 生物化学 - 结构生物学 - 神经科学 - 发展生物学 - 分子医学 - 药理学 - 微生物学 - 植物生物学与生物技术。

Biomolecular Concepts

Abstract Systemic lupus erythematosus (SLE) poses a diagnostic challenge due to its heterogeneity. This study examines the cardiac complications of SLE comprehensively, covering pericarditis, myocarditis, pleural effusion, valvular disease, atherosclerosis, and cardiac arrhythmias. Nearly one-third of SLE-related deaths are attributed to cardiovascular diseases, necessitating a deeper understanding of cardiac pathophysiology. The impact of SLE on the cardiovascular system manifests in various ways, including recurrent and resistant pericarditis, severe myocarditis, and pleural effusion. Valvular diseases, atherosclerosis, and cardiac arrhythmias are prevalent, with immune complex deposition playing a role in atherosclerosis. Diagnostic criteria involve clinical features, laboratory findings, and autoantibodies, emphasizing the need for early diagnosis and a multidisciplinary diagnostic approach. The review explores pharmacological and non-pharmacological modalities for managing cardiac manifestations in SLE. Recommendations include NSAIDs, colchicine, and proton pump inhibitors for acute pericarditis, while selective immunosuppressive therapy is emerging for myocarditis. Valvular diseases require individualized treatment approaches, and careful corticosteroid management is crucial to avoid increased cardiovascular events. Anti-malarial therapy, particularly hydroxychloroquine, shows promise in mitigating cardiovascular risk factors. Non-pharmacological modifications, such as diet, exercise, and smoke cessation, significantly contribute to cardiovascular health in SLE patients. Adjuvant therapies involving glutathione and glutathione peroxidase focus on redox balance, offering potential interventions. This integrated approach combines diagnostic insights with diverse treatment modalities, providing a holistic strategy for managing cardiac complications in SLE. Ongoing research is essential to refine these strategies and optimize individualized treatment plans for improved patient outcomes.

John Dawi

Scarlet Affa

Yura Misakyan

Sabrina Fardeheb

Samuel Kades

Anthony Kiriaki

Aishvaryaa Shree Mohan

Brandon Norris

Sonyeol Yoon

Vishwanath Venkentaraman

BioMolecular Concepts

Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches

探索系统性红斑狼疮中的心血管影响：并发症、诊断标准和治疗模式的全面分析，涵盖药物和辅助方法

Article Erratum to “Plant growth-promoting properties of bacterial endophytes isolated from roots of Thymus vulgaris L. and investigate their role as biofertilizers to enhance the essential oil contents” was published on January 1, 2022 in the journal Biomolecular Concepts (volume 13, issue 1).

Mahmoud Soliman Abdel-Hamid

Amr Fouda

Hesham Kamal Abo El-Ela

Abbas A. El-Ghamry

Saad El-Din Hassan

Erratum to “Plant growth-promoting properties of bacterial endophytes isolated from roots of <i>Thymus vulgaris</i> L. and investigate their role as biofertilizers to enhance the essential oil contents”

更正“从<i>Thymus vulgaris</i> L.根部分离的内生细菌的促植物生长特性及其作为生物肥料增强精油含量的作用研究”

One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women's lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of cervical cancer before the occurrence of clinical symptoms and prediction of cervical lesion behavior. The main aim of this review is to analyze publications in the field of precision medicine that allow the use of research knowledge of cervical microbiome, epigenetic modifications, and inflammation in potential application in clinical practice. Personalized approach in evaluating patient's risk of future development of cervical abnormality should consider the biomarkers of the local microenvironment characterized by the microbial composition, epigenetic pattern of cervical epithelium, and presence of chronic inflammation. Novel sequencing techniques enable a more detailed characterization of actual state in cervical epithelium. Better understanding of all changes in multiomics level enables a better assessment of disease prognosis and selects the eligible targeted therapy in personalized medicine. Restoring of healthy vaginal microflora and reversing the outbreak of cervical abnormality can be also achieved by dietary habits as well as uptake of prebiotics, probiotics, synbiotics, microbial transplantation, and others.

Veronika Holubekova

Zuzana Kolkova

Ivana Kasubova

Marek Samec

Alena Mazurakova

Lenka Koklesova

Peter Kubatka

Tomas Rokos

Erik Kozubik

Kamil Biringer

Erik Kudela

Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare

宫颈微生物群与上皮细胞表观基因组的相互作用：炎症对初级医疗保健的意义

Abstract MicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic expression and consequently of many cellular processes. But their expression is often deregulated in human tumors leading to cancer development. Recently miRNAs were discovered in body fluids (serum, plasma and others) and their levels have often been reported to be altered in patients. Circulating miRNAs became one of the most promising biomarkers in oncology for early diagnosis, prognosis and therapeutic response prediction. Here we describe the origins and roles of miRNAs, and summarize the most recent studies focusing on their usefulness as cancer biomarkers in lung, breast, colon, prostate, ovary cancers and melanoma. Lastly, we describe the main methodologies related to miRNA detection, which should be standardized for their use in clinical practice.

Virginie Armand-Labit

Anne Pradines

Circulating cell-free microRNAs as clinical cancer biomarkers

循环游离微小RNA作为临床癌症生物标志物

Abstract Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and oxidative stress appear implicated in its initiation and maintenance. Here, we show for the first time that circulating factors present in SSc sera increased reactive oxygen species (ROS) production, collagen synthesis, and proliferation of human pulmonary microvascular endothelial cells (HPMECs). The observed phenomena were also associated with endothelial to mesenchymal transition (EndMT) as indicated by decreased von Willebrand factor (vWF) expression and increased alpha-smooth muscle actin, respectively, an endothelial and mesenchymal marker. SSc-induced fibroproliferative effects were prevented by HPMECs exposition to the NADPH oxidase inhibitor diphenyleneiodonium, demonstrating ROS’s causative role and suggesting their cellular origin. Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples. Taking together our data indicate NADPH oxidase-induced EndMT as a potential mechanism of SSc-associated fibrosis, suggesting fibrosis-associated miRNAs as potentially responsible for initiating and sustaining the vascular alterations observed in this pathological condition.

Anna Maria Posadino

Gian Luca Erre

Annalisa Cossu

Costanza Emanueli

Ali H. Eid

Angelo Zinellu

Gianfranco Pintus

Roberta Giordo

NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs

NADPH衍生的ROS生成驱动系统性硬化症中的纤维化和内皮间充质转化：与循环miRNA的潜在交叉对话

Abstract Computational biology faces many challenges like protein secondary structure prediction (PSS), prediction of solvent accessibility, etc. In this work, we addressed PSS prediction. PSS is based on sequence-structure mapping and interaction among amino acid residues. We proposed an encoder–decoder with an attention mechanism model, which considers the mapping of sequence structure and interaction among residues. The attention mechanism is used to select prominent features from amino acid residues. The proposed model is trained on CB513 and CullPDB open datasets using the Nvidia DGX system. We have tested our proposed method for Q 3 and Q 8 accuracy, segment of overlap, and Mathew correlation coefficient. We achieved 70.63 and 78.93% Q 3 and Q 8 accuracy, respectively, on the CullPDB dataset whereas 79.8 and 77.13% Q 3 and Q 8 accuracy on the CB513 dataset. We observed improvement in SOV up to 80.29 and 91.3% on CullPDB and CB513 datasets. We achieved the results using our proposed model in very few epochs, which is better than the state-of-the-art methods.

Pravinkumar M. Sonsare

Chellamuthu Gunavathi

A novel approach for protein secondary structure prediction using encoder–decoder with attention mechanism model

一种基于注意力机制编码器-解码器模型的蛋白质二级结构预测新方法

Abstract Epigenetic analysis is a fundamental part of understanding pathophysiological processes with potential applications in diagnosis, prognosis, and assessment of disease susceptibility. Epigenetic changes have been widely studied in chronic obstructive pulmonary disease (COPD), but currently, there is no molecular marker used to improve the treatment of patients. Furthermore, this progressive disease is a risk factor for the development of more severe COVID-19. Methylation-specific polymerase chain reaction (MSP-PCR) plays an important role in the analysis of DNA methylation profiles, and it is one of the most widely used techniques. In this context, the combination of MSP-PCR with emerging PCR technologies, such as digital PCR (dPCR), results in more accurate analyses of the DNA methylation profile of the genes under study. In this study, we propose the application of the MSP-dPCR technique to evaluate the methylation profile of the ADAM33 gene from saliva samples and lung tissue biopsies of patients with COPD and COVID-19. MSP-dPCR generated a measurable prediction of gene methylation rate, with the potential application of this combined technology for diagnostic and prognostic purposes. It has also proven to be a powerful tool for liquid biopsy applications.

Gabriela Casani Cardoso

Fernando Augusto de Oliveira Ganzella

Guilherme Miniskiskosky

Regiane Stafim da Cunha

Edneia Amancio de Souza Ramos

Digital methylation-specific PCR: New applications for liquid biopsy

数字甲基化特异性PCR：液体活检的新应用

Abstract Alzheimer’s disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of β-amyloid (Aβ) peptide in the rat brain including the study of neuroinflammation, neurodegeneration, and alterations in peripheral immune responses (PIR). The neuroinflammation brought on by Aβ 1–42 and is unknown to influence PIR. Animal models were prepared, after 28 days, control, sham, and treated rats were anaesthetized and inflammatory markers of hippocampus and serum levels (reactive oxygen species, nitrite, tumor necrosis factor-α, and interleukin-1β), and some markers of PIR (splenic mononuclear cells or MNC, cytotoxicity and phagocytic index of the white blood cells leukocyte adhesion inhibition index or LAI), as well as polymorphonuclear cells of the spleen, were assessed. In addition to changes in peripheral immune responses, the present study found that AD rats had higher blood levels of inflammatory markers. Based on the study, the immune system irregularities observed in AD rats in the peripheral regions might be connected to neuroinflammation, which is facilitated by a compromised blood–brain barrier. Hence, it is viable to propose that the neuroinflammatory condition in rats with Aβ-induced AD could modify immune responses in the peripheral areas with significantly higher levels of inflammatory cytokines markers in the hippocampal tissue in Aβ-injected AD rats.

Krishnendu Adhikary

Satyajit Mohanty

Bidyut Bandyopadhyay

Rajkumar Maiti

Koushik Bhattacharya

Prithviraj Karak

β-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats

β-淀粉样肽调节大鼠外周免疫反应和神经炎症

Abstract Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes ( CDKN3 , TRAF6 , CCND1 , JAK1 , MET , AXIN2 , JAG1 , VEGFA , BRCA1 , E2F3 , WNT1 , CDK6 , KRAS , MYB , MYCN , TGFβR2 , NOTCH1 , SIRT1 , MYCN , NOTCH2 , WNT3A ) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein–protein interaction network analysis. CCND1 , CDK6 , and TRAF6 hub genes were predicted as targets of miR-34a-5p and miR-146a-5p, respectively. The study found the lower expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells, and further, it was observed that WA treatment effectively restored the lost expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells. An anti-correlation expression pattern was found among the miR-34a-5p and miR-146a-5p and the respective target hub genes in WA-treated TNBC cells. In conclusion, WA might exert anti-cancer effect in TNBC cells by inducing miR-34a-5p and miR-146a-5p expressions and decreasing CCND1, CDK6, and TARF6 target hub genes in TNBC cells.

Mohd Shuaib

Smriti Chaudhri

Shashank Kumar

Withaferin A alters the expression of microRNAs 146a-5p and 34a-5p and associated hub genes in MDA-MB-231 cells

醉茄内酯A改变MDA-MB-231细胞中微小RNA 146a-5p和34a-5p及其相关枢纽基因的表达

ISSN	1868-5021, 1868-503X
h-index	44

Publication Information	Publisher: Walter de Gruyter GmbH，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2010，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Journal Fees	$Details
Average review cycle	网友分享经验：12 Weeks

Biomolecular Concepts

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Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches

Erratum to “Plant growth-promoting properties of bacterial endophytes isolated from roots of Thymus vulgaris L. and investigate their role as biofertilizers to enhance the essential oil contents”

Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare

Circulating cell-free microRNAs as clinical cancer biomarkers

NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs

Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches

A novel approach for protein secondary structure prediction using encoder–decoder with attention mechanism model

Digital methylation-specific PCR: New applications for liquid biopsy

β-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats

Withaferin A alters the expression of microRNAs 146a-5p and 34a-5p and associated hub genes in MDA-MB-231 cells