当前化学主题对现代化学研究的当前和未来趋势进行了批判性评论。涵盖范围是化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的接口。每个专题合集的目标是为学术界或工业界的非专业读者提供全面的深入了解正在出现的新研究领域，这对更大的科学受众感兴趣。

Topics in Current Chemistry provides critical reviews of current and future trends in modern chemical research. It covers all areas of chemical science, including interfaces with related disciplines such as biology, medicine, physics, and materials science. Each thematic collection aims to offer a comprehensive understanding of emerging research fields for non-specialist readers in academia or industry, appealing to a broader scientific audience.

《Topics in Current Chemistry》对现代化学研究的当前和未来趋势进行了深入的批判性评论。该期刊涵盖化学科学的所有领域，包括与生物学、医学、物理学和材料科学等相关学科的交叉领域。每个专题合集旨在为学术界和工业界的非专业读者提供对新兴研究领域的全面理解，以满足更广泛科学受众的兴趣。

Topics in Current Chemistry

The benzoxazole is one of the most widely exploited heterocycles in drug discovery. Natural occurring and synthetic benzoxazoles show a broad range of biological activities. Many benzoxazoles are available for treating several diseases, and, to date, a few are in clinical trials. Moreover, an ever-increasing number of benzoxazole derivatives are under investigation in the early drug discovery phase and as potential hit or lead compounds. This perspective is an attempt to thoroughly review the rational design, the structure-activity relationship, and the biological activity of the most notable benzoxazoles developed during the past 5 years (period 2019-to date) in cancers, neurological disorders, and inflammation. We also briefly overviewed each target and its role in the disease. The huge amount of work examined suggests the great potential of the scaffold and the high interest of the scientific community in novel biologically active compounds containing the benzoxazole core.

Simona Di Martino

Maria De Rosa

Top Curr Chem (Cham)

The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents

苯并恶唑杂环：抗增殖、脑渗透和抗炎药物最新药物化学进展的综合评述

Coumarins are secondary metabolites made up of benzene and α-pyrone rings fused together that can potentially treat various ailments, including cancer, metabolic, and degenerative disorders. Coumarins are a diverse category of both naturally occurring as well as synthesized compounds with numerous biological and therapeutic properties. Coumarins as fluorophores play a key role in fluorescent labeling of biomolecules, metal ion detection, microenvironment polarity detection, and pH detection. This review provides a detailed insight into the characteristics of coumarins as well as their biosynthesis in plants and metabolic pathways. Various synthetic strategies for coumarin core involving both conventional and green methods have been discussed comparing advantages and disadvantages of each method. Conventional methods discussed are Pechmann, Knoevenagel, Perkin, Wittig, Kostanecki, Buchwald-Hartwig, and metal-induced coupling reactions such as Heck and Suzuki, as well as green approaches involving microwave or ultrasound energy. Various pharmacological applications of coumarin derivatives are discussed in detail. The structural features and conditions responsible for influencing the fluorescence of coumarin core are also elaborated.

Deepshikha Gupta

Eksha Guliani

Kiran Bajaj

Top Curr Chem (Z)

Coumarin—Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore

香豆素——合成方法、药理学及作为天然荧光团的应用

Separation of hydrocarbon mixtures into single components is a very important industrial process because all represent very important energy resources/raw chemicals in the petrochemical industry. The well-established industrial separation technology highly relies on the energy-intensive cryogenic distillation processes. The discovery of new materials capable of separating hydrocarbon mixtures by adsorbent-based separation technologies has the potential to provide more energy-efficient industrial processes with remarkable energy savings. Porous metal-organic frameworks (MOFs), also known as porous coordination polymers, represent a new class of porous materials that offer tremendous promise for hydrocarbon separations because of their easy tunability, designability, and functionality. A number of MOFs have been designed and synthesized to show excellent separation performance on various hydrocarbon separations. Here, we summarize and highlight some recent significant advances in the development of microporous MOFs for hydrocarbon separation applications.

Jiyan Pei

Kai Shao

Ling Zhang

Hui-Min Wen

Bin Li

Guodong Qian

Topics in current chemistry (Cham)

Current Status of Microporous Metal-Organic Frameworks for Hydrocarbon Separations.

微孔金属-有机框架在烃类分离中的研究现状

Abstract While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles. These innovations hold great promise for therapeutic interventions in personalized medicine and precision therapies. We also address existing challenges related to the selectivity and trafficking of subcellular dynamics. Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.

Veronika Šlachtová

Marek Chovanec

Michal Rahm

Milan Vrabel

Bioorthogonal Chemistry in Cellular Organelles

细胞器中的生物正交化学

DNA nanostructures hold great promise for various applications due to their remarkable properties, including programmable assembly, nanometric positional precision, and dynamic structural control. The past few decades have seen the development of various kinds of DNA nanostructures that can be employed as useful tools in fields such as chemistry, materials, biology, and medicine. Aptamers are short single-stranded nucleic acids that bind to specific targets with excellent selectivity and high affinity and play critical roles in molecular recognition. Recently, many attempts have been made to integrate aptamers with DNA nanostructures for a range of biological applications. This review starts with an introduction to the features of aptamer-functionalized DNA nanostructures. The discussion then focuses on recent progress (particularly during the last five years) in the applications of these nanostructures in areas such as biosensing, bioimaging, cancer therapy, and biophysics. Finally, challenges involved in the practical application of aptamer-functionalized DNA nanostructures are discussed, and perspectives on future directions for research into and applications of aptamer-functionalized DNA nanostructures are provided.

Xiaoyi Fu

Fangqi Peng

Jungyeon Lee

Qi Yang

Fei Zhang

Mengyi Xiong

Gezhi Kong

Hong-Min Meng

Guoliang Ke

Xiao-Bing Zhang

Aptamer-Functionalized DNA Nanostructures for Biological Applications.

用于生物应用的适配体功能化DNA纳米结构。

Porous materials have been gaining popularity in catalysis applications, solving the current ecological challenges. Metal-organic frameworks (MOFs) are especially noteworthy for their high surface areas and customizable chemistry, giving them a wide range of potential applications in catalysis remediation. The review study delves into the various applications of MOFs in catalysis and provides a comprehensive summary. This review thoroughly explores MOF materials, specifically focusing on their diverse catalytic applications, including Lewis catalysis, oxidation, reduction, photocatalysis, and electrocatalysis. Also, this study emphasizes the significance of high-performance MOF materials, which possess adjustable properties and exceptional features, as a novel approach to tackling technological challenges across multiple sectors. MOFs make it an ideal candidate for catalytic reactions, as it enables efficient conversion rates and selectivity. Furthermore, the tunable properties of MOF make it possible to tailor its structure to suit specific catalytic requirements. This feature improves performance and reduces costs associated with traditional catalysts. In conclusion, MOF materials have revolutionized the field of catalysis and offer immense potential in solving various technological challenges across different industries.

Virender Virender

Vandana Pandey

Gurjaspreet Singh

Pawan Kumar Sharma

Pankaj Bhatia

Alexander A Solovev

Brij Mohan

Hybrid Metal-Organic Frameworks (MOFs) for Various Catalysis Applications

混合金属-有机框架(MOFs)在多种催化应用中的研究

Utilising renewable energy to drive the conversion of carbon dioxide into more valuable products can effectively alleviate the energy crisis and protect the environment while actively responding to the policy of "carbon peaking and carbon neutrality". Additionally, formic acid/formate is one of the most promising and commercially valuable products of the electrocatalytic CO2 reduction reaction (ECO2RR) as well as a nonhazardous material for hydrogen storage. With the continuous progress in the field of electrocatalytic CO2 reduction to formic acid/formate (ECO2RF), various electrocatalysts with excellent performance have been developed. In this paper, first, the reaction mechanism of ECO2RF is briefly summarised, and then the recent research progress for various catalysts for ECO2RF, including metal-based catalysts, carbon-based material catalysts, metal-organic framework catalysts, covalent organic framework catalysts, and molecular catalysts, is reviewed. Finally, the current challenges and future perspectives of ECO2RF are discussed and presented.

Yuqi Ma

Rui Xu

Xiang Wu

Yilong Wu

Lei Zhao

Guizhi Wang

Fajun Li

Zhisheng Shi

Progress in Catalysts for Formic Acid Production by Electrochemical Reduction of Carbon Dioxide

电化学还原二氧化碳制备甲酸催化剂的研究进展

In cellular environments, certain synthetic molecules can form nanostructures via self-assembly, impacting molecular imaging, and biomedical applications. Control over the formation of these self-assembled nanostructures in subcellular organelle is challenging. By the action of stimuli, either present in the cellular environment or applied externally, in situ generation of molecular precursors can lead to accumulation and supramolecular nanostructure formation, resulting in efficient bioimaging. Here, we summarize smart fluorophore-based ordered nanostructure preparation at specific organelles for efficient bioimaging and therapeutic application towards cancer theranostics. We also present challenges and an outlook regarding intercellular self-assembly for theranostics application. Altogether, smart nanostructured materials with fluorescence read-outs at specific subcellular compartments would be beneficial in synthetic biology and precision therapeutics.

Dineshkumar Bharathidasan

Chandan Maity

Organelle-Specific Smart Supramolecular Materials for Bioimaging and Theranostics Application

用于生物成像和治疗诊断应用的细胞器特异性智能超分子材料

Transition metal-catalyzed cross-coupling with aryl halides has revolutionized the way of diversifying aromatic compounds. Aryl ethers are attractive alternatives to aromatic halides as coupling partners considering the accessibility and potential environmental benefits. The last two decades have witnessed a striking success in the field of C-O bond activation of aryl ethers, including the construction of C-C bond and C-X bond, as well as reductive deoxygenation. Here, we present a comprehensive review of C-O bond activation in the context of aryl, vinyl, and benzylic ethers. This review elaborates on the current state-of-the-art methods, categorized by different catalytic systems, including transition metal catalysis, photoredox catalysis, and other innovative approaches. The newly developed methods allow C-O bond activation under mild conditions with exceptional functional group tolerance, potentially enabling the late-stage functionalization of pharmaceuticals. The limitations and future perspectives of the methods are also presented.

Pengfei Li

Mingyu Zhang

Lei Zhang

Recent Advances in C–O Bond Cleavage of Aryl, Vinyl, and Benzylic Ethers

芳基、乙烯基和苄基醚C-O键断裂的最新进展

In recent years, porous polymers have gained significant attention for their application as powerful and selective sorbents in micro solid phase extraction (µSPE). In this review we explore the preparation and utilization of various porous polymer sorbents, highlighting their impact on enhancing µSPE techniques. Molecularly imprinted polymers (MIPs), graphene oxide-modified frameworks, and zeolitic imidazole frameworks (ZIFs) are among the innovative materials discussed. These innovative materials have significantly improved µSPE methods, offering enhanced extraction efficiencies, superior selectivity, and reduced solvent consumption, all of which align with the principles of green chemistry. Key findings of this review include the demonstration that MIPs exhibit excellent target specificity, making them ideal for complex matrices, while graphene oxide frameworks and ZIFs provide increased surface area and stability for diverse analytical applications. Despite these advancements, challenges remain, particularly the high cost of certain innovative materials, limited reusability, and the absence of automation in µSPE workflows. Furthermore, controlling the precise synthesis and functionalization of these sorbents continues to be a limiting factor. To address these issues, future research should focus on developing cost-effectiveness methods, the use of biopolymer or sustainable feedstocks, and scalable synthesis methods; integrating automation into µSPE; and exploring new polymeric materials with enhanced properties. Additionally, novel hybrid materials that combine the strengths of multiple sorbents offer a promising direction for future exploration. We critically analyze the advantages and limitations of each sorbent type, providing a comprehensive overview of their applications in µSPE. This paper also examines the synthesis, characterization, and unique properties of these porous polymers, emphasizing their role in advancing analytical chemistry towards more efficient and environmentally friendly practices. The need for continued development of high-performance, low-cost, and sustainable sorbents is underscored to further enhance the effectiveness of µSPE techniques.

Sayyed Hossein Hashemi

Massoud Kaykhaii

Porous Polymer Sorbents in Micro Solid Phase Extraction: Applications, Advantages, and Challenges

多孔聚合物吸附剂在微固相萃取中的应用、优势与挑战

Abbreviation	Top Curr Chem (Z)
Journal Impact	7.19
Quartiles(Global)	CHEMISTRY, MULTIDISCIPLINARY(Q1)

ISSN	2364-8961, 2365-0869
h-index	110

Publication Information	Publisher: Springer Verlag，Publishing cycle: Irregular，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2004，Proportion of original research papers: 0.00%，Self Citation Rate:1.40%， Gold OA Rate: 16.79%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：较难

Topics in Current Chemistry

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