ANNALS OF BIOMEDICAL ENGINEERING是生物医学工程学会的官方期刊，发表生物工程和生物医学工程主要领域的原创文章。 《年鉴》是一本跨学科的国际期刊，旨在突出解决生物和生物医学问题的综合方法。

The Annals of Biomedical Engineering is the official journal of the Biomedical Engineering Society, dedicated to publishing original research articles in the fields of bioengineering and biomedical engineering. This interdisciplinary international journal aims to highlight integrated approaches to solving biological and biomedical problems.

《Annals of Biomedical Engineering》是生物医学工程学会的官方期刊，专注于发表生物工程和生物医学工程领域的原创研究文章。这本跨学科的国际期刊旨在强调解决生物和生物医学问题的综合方法。

Annals of Biomedical Engineering

Prompt engineering is a relatively new discipline that refers to the practice of developing and optimizing prompts to effectively utilize large language models, particularly in natural language processing tasks. However, not many writers and researchers are familiar about this discipline. Hence, in this paper, I aim to highlight the significance of prompt engineering for academic writers and researchers, particularly the fledgling, in the rapidly evolving world of artificial intelligence. I also discuss the concepts of prompt engineering, large language models, and the techniques and pitfalls of writing prompts. Here, I contend that by acquiring prompt engineering skills, academic writers can navigate the changing landscape and leverage large language models to enhance their writing process. As artificial intelligence continues to advance and penetrate the arena of academic writing, prompt engineering equips writers and researchers with the essential skills to effectively harness the power of language models. This enables them to confidently explore new opportunities, enhance their writing endeavors, and remain at the forefront of utilizing cutting-edge technologies in their academic pursuits.

Louie Giray

Annals of biomedical engineering

Ann Biomed Eng

Prompt Engineering with ChatGPT: A Guide for Academic Writers.

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

Weiwei Gao

Yue Zhang

Qiangzhe Zhang

Liangfang Zhang

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

纳米颗粒-水凝胶：一种用于局部药物递送的混合生物材料系统

With the recent revolution in Molecular Biology and the deciphering of the Human Genome, understanding of the building blocks that comprise living systems has advanced rapidly. We have yet to understand, however, how the physical forces that animate life affect the synthesis, folding, assembly, and function of these molecular building blocks. We are equally uncertain as to how these building blocks interact dynamically to create coupled regulatory networks from which integrative biological behaviors emerge. Here we review recent advances in the field of biomechanics at the cellular and molecular levels, and set forth challenges confronting the field. Living systems work and move as multi-molecular collectives, and in order to understand key aspects of health and disease we must first be able to explain how physical forces and mechanical structures contribute to the active material properties of living cells and tissues, as well as how these forces impact information processing and cellular decision making. Such insights will no doubt inform basic biology and rational engineering of effective new approaches to clinical therapy.

Dennis Discher

Cheng Dong

Jeffrey J Fredberg

Farshid Guilak

Donald Ingber

Paul Janmey

Roger D Kamm

Geert W Schmid-Schönbein

Sheldon Weinbaum

Biomechanics: cell research and applications for the next decade.

生物力学：未来十年的细胞研究与应用。

Hydrogels appear to be an attractive class of biomaterial for cartilage tissue engineering due to their high water content, excellent biocompatibility, tunable stiffness, etc. The crosslinking density of the hydrogel can affect their viscoelastic property, and therefore potentially impact the chondrogenic phenotype of re-differentiated chondrocytes in a 3D microenvironment through physical cues. To understand the effect of crosslinking densities on chondrocytes phenotype and cellular interaction with the hydrogel, this study utilized a clinical grade thiolate hyaluronic acid and thiolate gelatin (HA-Gel) hydrogel, crosslinked with poly(ethylene glycol) diacrylate to create various crosslinking densities. The HA-Gel hydrogels were then mixed with human nasal chondrocytes to generate neocartilage in vitro. The influence of the hydrogel crosslinking density and the viscoelastic property on the cell behaviours on the gene and matrix levels were evaluated using biochemistry assays, histology, quantitative polymerase chain reaction (qPCR) and next-generation sequencing (RNA seq). In general, the differences in the storage modulus of the HA-Gel hydrogel are not enough to alter the cartilaginous gene expression of chondrocytes. However, a positively correlated trend of PPAR-γ gene expression to the crosslinking density was measured by qPCR. The RNA-seq results have shown that 178 genes are significantly negatively correlated and 225 genes are positively correlated to the crosslinking density, which is worth investigating in the future studies.

Xiaoyi Lan

Zhiyao Ma

Melanie Kunze

Aillette Mulet-Sierra

Martin Osswald

Khalid Ansari

Hadi Seikaly

Yaman Boluk

Adetola B Adesida

The Effect of Crosslinking Density on Nasal Chondrocytes' Redifferentiation.

交联密度对鼻软骨细胞再分化的影响。

The biomechanical interaction of stents and the arteries into which they are deployed is a potentially important consideration for long-term success. Adverse arterial reactions to excessive stress and the resulting damage have been linked to the development of restenosis. Complex geometric features often encountered in these procedures can confound treatment. In some cases, it is desirable to deploy a stent across a region in which the diameter decreases significantly over the length of the stent. This study aimed to assess the final arterial diameter and circumferential stress in tapered arteries into which two different stents were deployed (one stiff and one less stiff). The artery wall was assumed to be made of a strain stiffening material subjected to large deformations, with a 10% decrease in diameter over the length of the stent. A commercially available finite element code was employed to solve the contact problem between the two elastic bodies. The stiffer stent dominated over arterial taper, resulting in a nearly constant final diameter along the length of the stent, and very high stresses, particularly at the distal end. The less stiff stent followed more closely the tapered contour of the artery, resulting in lower artery wall stresses. More compliant stents should be considered for tapered artery applications, perhaps even to the exclusion of tapered stents.

Lucas H Timmins

Clark A Meyer

Michael R Moreno

James E Moore

Mechanical modeling of stents deployed in tapered arteries.

锥形动脉中支架展开的力学建模。

Abstract Vacuum-assisted delivery (VAD) uses a vacuum cup on the fetal scalp to apply traction during uterine contractions, assisting complicated vaginal deliveries. Despite its widespread use, VAD presents a higher risk of neonatal morbidity compared to natural vaginal delivery and biomechanical evidence for safe VAD traction forces is still limited. The aim of this study is to develop and assess the feasibility of an experimental VAD testing setup, and investigate the impact of traction forces on fetal brain deformation. A patient-specific fetal head phantom was developed and subjected to experimental VAD in two testing setups: one with manual and one with automatic force application. The skull phantom was 3D printed using multi-material Polyjet technology. The brain phantom was cast in a 3D-printed mold using a composite hydrogel, and sonomicrometry crystals were used to estimate the brain deformation in three brain regions. The experimental VADs on the fetal head phantom allowed for quantifying brain strain with traction forces up to 112 N. Consistent brain crystal movements aligned with the traction force demonstrated the feasibility of the setup. The estimated brain deformations reached up to 4% and correlated significantly with traction force ( p &lt; 0.05) in regions close to the suction cup. Despite limitations such as the absence of scalp modeling and a simplified strain computation, this study provides a baseline for numerical studies and supports further research to optimize the safety of VAD procedures and develop VAD training platforms.

Estelle Pitti

Lotta Herling

Xiaogai Li

Gunilla Ajne

Matilda Larsson

Experimental Assessment of Traction Force and Associated Fetal Brain Deformation in Vacuum-Assisted Delivery

真空辅助分娩中牵引力及相关的胎儿脑部变形的实验评估

Shins are one of the most vulnerable bones in human body. Shin guards are evaluated by their effectiveness in reducing the force applied to the bone. In this study, a structural modified mechanical lumped model of the shin guard was developed to provide maximum force distribution using physical parameter change modification technique and genetic algorithm. Modal analysis and finite element methods were used to determine the dynamic behavior of the system in the frequency range of 0-3000 Hz. In this research, FE results had an encouraging agreement with those in experimental test with a Mean Absolute Error (MAE) found as 34.94. The results proposed two design zones to select the stiffness of the shin guard. The stiffnesses K1 and K2 were selected between the values in the design zones. For situation, K1 = 7.9 × 105 N/m and K2 = 6.3 × 105 N/m, the distribution parameter was equal to 76% and f1 = 1.87F, f2 = 0.71F f3 = 1.81F, meaning the force was effectively distributed.

Ehsan Moghaddam

Aref Afsharfard

Developing a Structurally Modified Mechanical Lumped Model of the Human Tibia and Shin Guard Using Modal Analysis

开发基于模态分析的人体胫骨与护腿板结构改良机械集中模型

Cerebral edema is associated with poor prognosis because brain swelling within the rigid skull raises intracranial pressure, exacerbating secondary injuries following traumatic brain injury. Brain swelling can be characterized by triphasic biomechanics, which models brain tissue as a mixture of a deformable porous solid matrix with a negative fixed-charged density (FCD), water, and monovalent counterions. When brain cells die, the intracellular FCD is exposed, attracting cations into the cells. The increase in intracellular solute concentration generates osmotic pressure via the Gibbs-Donnan effect, driving water into cells and causing swelling. This study quantifies the FCD of rat and pig brain tissue by measuring the pressure generated by tissue within a confined volume as cells died. Rat brain tissue generated an averaged swelling pressure of 52.92 ± 20.40 mmHg (mean ± one standard deviation). Variations were observed between pig cortical white matter (7.14 ± 4.79 mmHg) and cortical gray matter (33.86 ± 11.89 mmHg). The corresponding FCD values were 42.54 ± 8.14 mEq/L for rat brain tissue, and 15.18 ± 5.38 mEq/L and 34.22 ± 6.31 mEq/L for pig cortical white and gray matter, respectively. Treating the rat brain tissue with DNAse, heparinase I, heparinase III, and chondroitinase ABC to degrade FCD significantly reduced swelling pressure. Good agreement between the experimental and numerically simulated responses supported the role of the FCD in cerebral edema formation. The reported FCD values can improve the biofidelity of computational models to predict post-traumatic cerebral edema, aiding the improvement of safety systems.

Delin Zeng

Andrew V. Basilio

Leanne A. Pichay

Gerard A. Ateshian

Olivia S. Hansen

Alexander Romanov

Barclay Morrison

Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue

大鼠和猪脑组织中固定电荷密度的实验测量与数学量化

Abstract The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10 −6 g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight. In this study, we encapsulated human chondrocytes in an agarose gel of similar stiffness to the pericellular matrix to mimic the cartilage microenvironment. We then exposed agarose-chondrocyte constructs to simulated microgravity (SM) for four days using a rotating wall vessel (RWV) bioreactor to better assess the cartilage health risks associated with spaceflight. Metabolites extracted from media and agarose gel constructs were analyzed on liquid chromatography-mass spectrometry. Global metabolomic profiling detected a total of 1205 metabolite features, with 497 significant metabolite features identified by ANOVA (FDR-corrected p -value &lt; 0.05). Specific metabolic shifts detected in response to SM exposure resulted in clusters of co-regulated metabolites, with glutathione, nitrogen, histidine, vitamin B 3 , and aminosugars metabolism identified by variable importance in projection scores. Microgravity-induced metabolic shifts in gel constructs and media were indicative of protein synthesis, energy and nucleotide metabolism, and oxidative catabolism. Microgravity associated-metabolic shifts were consistent with our previously published early osteoarthritic metabolomic profiles in human synovial fluid, suggesting that even short-term exposure to microgravity (or other reduced mechanical loading environments) may lead to the development of OA. This work further suggests the potential to detect these metabolic perturbations in synovial fluid in vivo to ascertain osteoarthritis risk in astronauts.

Annika R. Bergstrom

Matthew G. Glimm

Eden A. Houske

Gwendolyn Cooper

Ethan Viles

Marrin Chapman

Katherine Bourekis

Hope D. Welhaven

Priyanka P. Brahmachary

Alyssa K. Hahn

Ronald K. June

Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity

封装软骨细胞暴露于短期模拟微重力下的代谢特征

Abstract Purpose We compared adults with mitral stenosis (MS) to 8 controls (CONT) to see how pulmonary impedance and wave reflections differ at baseline and after balloon valvuloplasty. Methods We separated the MS patients into groups according to mean pulmonary artery pressure: moderate (MOD; ≤ 26 mmHg, n = 21) and high (HIGH; &gt; 26 mmHg, n = 33). We made baseline high-fidelity measurements in all patients, in the MS groups after vasodilation with nitroprusside, immediately and 4 months after balloon valvuloplasty. Results Comparing MOD vs CONT, using the Kruskal-Wallis test with Bonferroni correction, reveals evidence for higher baseline input resistance (R) (489 vs 205 dyne-sec/cm 5 , P = 0.07); first harmonic of impedance modulus (Z 1 ) (97.3 vs 27.6 dyne-sec/cm 5 , P = 0.01); first zero crossing of impedance phase angle (F 0 ) (4.49° vs 2.19°, P = 0.02) but no difference in wave reflection index (P b /P f ). Baseline HIGH vs CONT comparisons reveal stronger evidence and larger differences than MOD for R (995 vs 205, P &lt; 0.001); Z 1 (151 vs 27.6, P &lt; 0.001); F 0 (5.25 vs 2.19, P &lt; 0.001); as well as P b /P f (0.69 vs 0.42, P &lt; 0.001). Responses to nitroprusside and valvuloplasty are also greater in the HIGH than MOD, but the HIGH parameters still differ from the CONT. Four months after valvuloplasty there is evidence for reverse remodeling in both groups. Further analyses reveal that sinus rhythm and younger age are potentially important factors for remodeling. Conclusion MS causes alterations in pulmonary hemodynamics that differ according to pressure levels. These changes are only partially reversed immediately after valvuloplasty. There is evidence for reverse remodeling 4 months afterwards.

Chih-Tai Ting

Jaw-Wen Chen

Mau-Song Chang

Frank C.-P. Yin

Pulmonary Impedance and Wave Reflections in Adults with Mitral Stenosis: Immediate and Follow-Up Effects of Balloon Valvuloplasty

二尖瓣狭窄成人患者的肺阻抗及波反射：球囊瓣膜成形术的即刻及随访效果

Abbreviation	Ann Biomed Eng
Journal Impact	2.91
Quartiles(Global)	ENGINEERING, BIOMEDICAL(Q3)

ISSN	0090-6964, 1573-9686
h-index	156

Publication Information	Publisher: Springer，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1972，Proportion of original research papers: 88.73%，Self Citation Rate:10.00%， Gold OA Rate: 25.90%
Average review cycle	网友分享经验：平均3.0个月
Average recruitment ratio	网友分享经验：容易

Annals of Biomedical Engineering

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